{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:49:59Z","timestamp":1792298999769,"version":"4.4.0"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:00:00Z","timestamp":1345075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>Papadopoulos M. A., Koumpridou E. N., Vakalis M. L., Papageorgiou S. N. \u2028Effectiveness of pre\u2010surgical infant orthopedic treatment for cleft lip and palate patients: a systematic review and meta\u2010analysis \u2028<jats:italic>Orthod Craniofac Res<\/jats:italic> 2012;<jats:bold>15<\/jats:bold>:207\u2013236. \u00a9 2012 John Wiley &amp; Sons A\/S<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The objective of the study was to systematically summarize current evidence on the effectiveness of pre\u2010surgical infant orthopedics (PSIO) in cleft lip and palate (CLP) patients. Electronic and manual searches were conducted, and using specific inclusion and exclusion criteria, data extraction and analysis was performed by two independent investigators. When possible, overall pooled estimates with 95% confidence intervals were obtained using the random\u2010effects model. Twenty\u2010four of 885 original studies met the inclusion criteria and were included in the qualitative synthesis, whereas 10 of them were included in the quantitative synthesis (meta\u2010analysis). Except for the variable M\u2010T\u2010C(5) assessing maxillary arch form, which presented an increase at 48\u2003months of follow\u2010up, all other variables concerning craniofacial and dentoalveolar changes demonstrated no significant differences, indicating that PSIO treatment has no effect on CLP patients. The limited evidence derived from this study does not seem to support the short\u2010 or long\u2010term effectiveness of PSIO in CLP patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1601-6343.2012.01552.x","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T09:29:09Z","timestamp":1345109349000},"page":"207-236","source":"Crossref","is-referenced-by-count":67,"title":["Effectiveness of pre\u2010surgical infant orthopedic treatment for cleft lip and palate patients: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"M. A.","family":"Papadopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. N.","family":"Koumpridou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Vakalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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