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Als diagnostische Kriterien gelten der serologische Nachweis von hohen Antik\u00f6rpertitern gegen U1RNP und das Vorkommen von mindestens 3 der 5 folgenden klinischen Symptome: \u00d6dem der H\u00e4nde, Synovitis, Myositis, Raynaud\u2010Ph\u00e4nomen und Akrosklerose. Pathogenetisch werden neben genetischen auch infekti\u00f6se (virale) Aspekte diskutiert. Die Anerkennung der MCTD als eigene Krankheitsentit\u00e4t ist nicht unumstritten, Bezeichnungen wie \u201eundifferenzierte Bindegewebserkrankung\u201d oder \u201e\u00dcberlappungssyndrome\u201d helfen nicht weiter. Jeweils ein Viertel bzw. ein Drittel der MCTD\u2010Patienten gehen im Krankheitsverlauf in einen LE bzw. in eine SSc \u00fcber. Therapeutisch werden Glukokortikoide in Kombination mit Immunsuppressiva sowie Endothelin\u2010Rezeptor\u2010Antagonisten empfohlen. Doppelblindstudien fehlen. Die Prognose ist relativ gut. Unter den Todesursachen dominieren pulmonale Hypertonie, respiratorische und Herzinsuffizienz sowie Infektionen.<\/jats:p>","DOI":"10.1111\/j.1610-0378.2005.04089.x","type":"journal-article","created":{"date-parts":[[2005,2,11]],"date-time":"2005-02-11T15:40:55Z","timestamp":1108136455000},"page":"97-104","source":"Crossref","is-referenced-by-count":5,"title":["MCTD \u2013 Mixed Connective Tissue Disease"],"prefix":"10.1111","volume":"3","author":[{"given":"Uwe\u2010Frithjof","family":"Haustein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,11]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90064-2"},{"key":"e_1_2_12_3_2","unstructured":"KasukawaR SharpGC. Mixed connective tissue diseases and anti\u2010nuclear antibodies. 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