{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:46:37Z","timestamp":1781657197601,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T00:00:00Z","timestamp":1146614400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:italic>Background:<\/jats:italic> Until recently, no prescription drug containing permethrin for the therapy of scabies was available on the German market.Therefore, a 5% permethrin cream formulation (InfectoScab<jats:sup>\u00ae<\/jats:sup> 5%) was tested in a single\u2010arm multi\u2010center study including adults and children from 3 months of age with proven scabies.<\/jats:p><jats:p> <jats:italic>Patients and Methods:<\/jats:italic> On day 0, patients were treated once with permethrin cream in the study center. Control examinations including dermatoscopy were performed on day 14\u00b12 and on day 28\u00b13. Patients who were not considered cured or who had contact to individuals with untreated scabies received one further treatment with permethrin cream on day 14\u00b12. Itching and local tolerability of the cream were documented in patients' diaries. Side effects were assessed by history, skin inspection and evaluation of patients' notes.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> 106 patients in 13 centers were enrolled in the study. Their mean age was 29.2 years (range, 141 days to 71.9 years); 34% of them were children or adolescents. 78.3% of patients were either severely (3 body sites) or very severely (4\u20135 sites) affected. The cure rate on day 28\u00b13 was 95.1% (95% confidence interval, 91.0\u201399.3%). Pruritus declined markedly and continuously. In general, the cream was well tolerated; side effects were almost invariably mild.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> Our results support the efficacy and safety of 5% permethrin cream in adults, children and infants suffering from scabies. These results have contributed to the approval of InfectoScab<jats:sup>\u00ae<\/jats:sup> 5% in Germany for the treatment of scabies in October 2004.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2006.05941.x","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T13:03:46Z","timestamp":1146661426000},"page":"407-413","source":"Crossref","is-referenced-by-count":31,"title":["Treatment of scabies with 5% permethrin cream: results of a German multicenter study"],"prefix":"10.1111","volume":"4","author":[{"given":"Henning","family":"Hamm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Beiteke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"H\u00f6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia S.","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diamant","family":"Thaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cord","family":"Sunderk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70263-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1001\/archderm.1990.01670260037006","article-title":"Comparative study of 5% permethrin cream and 1% lindane lotion for the treatment of scabies","volume":"126","author":"Schultz MW","year":"1990","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb03958.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000320"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1990.tb01078.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21515.x"},{"key":"e_1_2_6_8_2","unstructured":"Regulation (EC) No 850\/2004 of the European Parliament and of the Council of 29 April 2004 on persistent organic pollutants and amending Directive 79\/117\/EEC. 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