{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:46:49Z","timestamp":1761630409240},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T00:00:00Z","timestamp":1144022400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:italic>Background:<\/jats:italic> The Ehlers\u2010Danlos syndrome encompasses a group of hereditary disorders of the connective tissue, characterized by hyperextensible skin, joint hypermobility; and varying degrees of vessel and tissue fragility. The main forms are classical,hypermobile,vascular,kyphoscoliotic A\/B,arthrochalasis A\/B and dermatosparaxis types.<\/jats:p><jats:p> <jats:italic>Patients and Methods:<\/jats:italic> We report our experience in diagnosis and classification of Ehlers\u2010Danlos\u2010syndrome, especially with the combination of clinical and morphological criteria, at the Department of Dermatology of the University of Heidelberg with more than 600 patients between 1984 and 2004.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> We classified those types of EDS which are characterized by regular and characteristic ultrastructural changes in the dermal components, primarily collagen, including the classical, hypermobile and vascular types as well as the less\u2010common arthrochalasis and dermatosparaxis types. The combination of clinical and morphologic features facilitates the selection of candidate genes for molecular genetic investigation.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> Besides the skin, skeleton and vessels, many other organ systems such as eyes and intestine, can be affected in Ehlers\u2010Danlos syndrome. Accordingly, interdisciplinary cooperation (pediatrics, surgery, orthopedics, rheumatology, neurology, genetics) is necessary. As the connective tissue of the skin is accessible for biopsy and diagnostic investigation, dermatologists should be trained in the diagnostic approach and classification of this syndrome.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2006.05958.x","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T08:56:38Z","timestamp":1144054598000},"page":"308-318","source":"Crossref","is-referenced-by-count":37,"title":["Ehlers\u2010Danlos syndrome \u2013 20 years experience with diagnosis and classification"],"prefix":"10.1111","volume":"4","author":[{"given":"Sylvia","family":"Proske","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Hartschuh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Enk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Hausser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,3]]},"reference":[{"key":"e_1_2_17_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2005.00401.x"},{"key":"e_1_2_17_3_2","first-page":"351","volume-title":"Connective tissue and its heritable disorders","author":"Steinmann B","year":"2002"},{"key":"e_1_2_17_4_2","first-page":"1777","article-title":"The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS)","volume":"27","author":"Grahame R","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_17_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_17_6_2","first-page":"394","article-title":"Differential ultrastructural aberrations of collagen fibrils in Ehlers\u2010Danlos syndrome types I\u2010IV as a means of diagnostics and classification","volume":"3","author":"Hausser I","year":"1994","journal-title":"Hum Genet"},{"key":"e_1_2_17_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340118"},{"key":"e_1_2_17_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050049"},{"key":"e_1_2_17_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050898"},{"key":"e_1_2_17_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(97)00007-9"},{"key":"e_1_2_17_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970110)68:1<25::AID-AJMG5>3.0.CO;2-X"},{"key":"e_1_2_17_12_2","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1001\/archderm.1993.01680310080014","article-title":"Dermatosparaxis in children. 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