{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T10:38:37Z","timestamp":1725705517462},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T00:00:00Z","timestamp":1150675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A 78\u2010year\u2010old male sought dermatologic consultation for multifocal persistent red lesions of the glans penis. Various topical treatments had proved unsuccessful. Histologic examination revealed penile intraepithelial neoplasia (PIN). Polymerase chain reaction (PCR) showed amplification of human papillomavirus type 16 (HPV\u201016) DNA. Urological consultants recommended amputation of the glans; the patient rejected this, as well as any other surgical procedure.<\/jats:p><jats:p>Therefore, he was treated in our dermatologic practice with imiquimod 5 % cream administered daily over 12 weeks. After therapy was completed, no clinical or histologic evidence of residual tumor was found and HPV\u201016 DNA was no longer detectable. Local skin reactions such as erosions and edema of the glans accompanied by tingling and itching were well\u2010tolerated by the patient. Imiquimod 5 % cream may represent an alternative local treatment option for multifocal PIN.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2006.06005.x","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T16:27:13Z","timestamp":1150734433000},"page":"559-561","source":"Crossref","is-referenced-by-count":5,"title":["Multifocal penile intraepithelial neoplasia \u2014 targeted treatment with imiquimod"],"prefix":"10.1111","volume":"4","author":[{"given":"Thomas","family":"Dirschka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Krahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Oster\u2010Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,19]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05019.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66967-2"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01151.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1258\/0956462042563774"},{"key":"e_1_2_4_6_2","first-page":"278","article-title":"Bowenoid papulosis in a patient with AIDS treated with imiquimod: case report","volume":"12","author":"Nunes Mde G","year":"2004","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0506"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37245-2"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90611-8"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0094-0143(21)00392-X","article-title":"Mohs micrographic surgery for penile tumors","volume":"19","author":"Mohs FE","year":"1992","journal-title":"Urol Clin North Am"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(90)80181-L"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.126580"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197610)38:4<1498::AID-CNCR2820380409>3.0.CO;2-#"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0366-077X.2003.05635.x"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02720.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2004.08.007"},{"key":"e_1_2_4_17_2","first-page":"705","article-title":"Therapy of cutaneous squamous cell carcinoma in two retirement home residents","volume":"3","author":"Oster\u2010Schmidt C","year":"2005","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1179\/095741905X41267"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1610-0387.2006.06005.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1610-0387.2006.06005.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:58:10Z","timestamp":1696985890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1610-0387.2006.06005.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,19]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1610-0387.2006.06005.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1610-0387.2006.06005.x","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,19]]}}}