{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T13:46:55Z","timestamp":1724680015828},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Infantile acne is a rare condition which usually begins after the third month of life and appears mainly on the cheeks. Spontaneous healing typically occurs within 2 years. A 2\u2010year\u2010old boy developed acne infantum during the first days after birth; it failed to respond to topical treatment. Detailed physical examination and endocrinologic evaluation confirmed the presumed diagnosis of congenital adrenal hyperplasia (CAH), and showed it was caused by 11\u2010beta\u2010hydroxylase deficiency.<\/jats:p><jats:p>CAH comprises a group of autosomal\u2010recessively inherited disorders. These hereditary enzyme defects in steroid biosynthesis cause glucocorticoid deficiency and an overproduction of biosynthetic precursor steroids. Adrenal androgen biosynthesis is not impaired but shows a massive reactive overproduction due to the increased ACTH secretion within the up\u2010regulated hypothalamo\u2010pituitary\u2010adrenal system. The characteristic features of CAH in male infants are demonstrated on the basis of this case report.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2006.06016.x","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T20:20:59Z","timestamp":1153254059000},"page":"654-657","source":"Crossref","is-referenced-by-count":11,"title":["Acne infantum as presenting symptom of congenital adrenal hyperplasia due to 11\u2010beta\u2010hydroxylase deficiency"],"prefix":"10.1111","volume":"4","author":[{"given":"Viola","family":"Harde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang G.","family":"Sippell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"F\u00f6lster\u2010Holst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2001.04397.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017838"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1997.tb00420.x"},{"key":"e_1_2_6_5_2","first-page":"306","article-title":"Acne conglobata infantum","volume":"13","author":"Wagner G","year":"1987","journal-title":"Akt Dermatol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1990.tb02119.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.15.4.421"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000023374"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000067819"},{"key":"e_1_2_6_10_2","first-page":"306","article-title":"Infantile acne associated with transient increases of plasma concentrations of luteinizing hormone, follicle\u2010stimulating hormone undtestosterone","volume":"13","author":"Duke EMC","year":"1987","journal-title":"Akt Dermatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70238-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90122-1"},{"key":"e_1_2_6_13_2","volume-title":"Dermatologie, Venerologie. 2","author":"Fritsch P","year":"2003"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1610-0387.2006.06016.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1610-0387.2006.06016.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T01:00:05Z","timestamp":1696986005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1610-0387.2006.06016.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,18]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1610-0387.2006.06016.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1610-0387.2006.06016.x","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,18]]}}}