{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:03:55Z","timestamp":1787015035794,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T00:00:00Z","timestamp":1158624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background:<\/jats:italic>\n                    Lichen sclerosus (LS) has been identified with increased frequency in families,often associated with HLA markers, mainly DQ7. A genetic co\u2010etiology seems likely in this setting. Moreover, there is an association of LS with autoimmune disorders, such as the presence of anti\u2010thyroid peroxidase autoantibodies (anti\u2010TPO), a hallmark of autoimmune thyroid diseases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients and Methods:<\/jats:italic>\n                    In 3 families affected by LS, we verified their HLA markers, and identified previously undiagnosed cases of LS and autoimmune disorders. 30 individuals were examined with history, skin biopsy, HLA class I and II typing by PCR\u2010SSP, and measurement of anti\u2010TPO, free thyroxine and thyroidstimulating hormones (TSH) levels.\n                    <jats:italic>Results:<\/jats:italic>\n                    There were 8 cases of LS, 50 % of them anti\u2010TPO+. Autoimmune disorders were found in 40 % (total) and in 87.5 % of those affected. Most common HLA markers were B*15, B*57, CW*03, CW*07, CW*18, DRB1*04, DRB1*07, DRB4*. The three latter have been previously associated with LS.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion:<\/jats:italic>\n                    New cases of LS and autoimmune disorders can be detected in first degree relatives of patients with LS. The presence of anti\u2010TPO antibodies strongly suggests autoimmune thyroiditis. There is intra\u2010familial association between the haplotype HLA\u2010B*15 \u2010DRB1*04 \u2010DRB4* and anti\u2010TPO,emphasizing their link with thyroiditis. New familial approaches might help to make clear the pathogenesis of LS and its association with autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1111\/j.1610-0387.2006.06087.x","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T09:14:39Z","timestamp":1158657279000},"page":"842-847","source":"Crossref","is-referenced-by-count":37,"title":["HLA markers in familial Lichen Sclerosus"],"prefix":"10.1111","volume":"4","author":[{"given":"Flavia M. N. P.","family":"Aslanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa Q.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroldo J.","family":"Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane F. S.","family":"Pontes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Crist\u00f3v\u00e3o S.","family":"Porto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia M. S.","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Absalom L.","family":"Filgueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08228-2"},{"key":"e_1_2_5_3_2","first-page":"172","volume-title":"The Vulva","author":"Ridley CM","year":"1988"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb02831.x"},{"issue":"62","key":"e_1_2_5_5_2","first-page":"33","article-title":"Familial lichen sclerosus","volume":"147","author":"Salim A","year":"2002","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03360.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb05013.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02611.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23905.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1981.tb08172.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5936.78"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb01748.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1740-2557-2-2"},{"issue":"10","key":"e_1_2_5_14_2","first-page":"932","article-title":"Study on the risk factors of 100 cases with vulvar dystrophy","volume":"24","author":"Tang GX","year":"2003","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_5_15_2","first-page":"284","volume-title":"Fundamentals of Genetic Epidemiology","author":"Meyers DA","year":"1993"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)00089-9"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.3.943"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916939209083135"},{"key":"e_1_2_5_19_2","unstructured":"WildD.The immunoassay handbook first edition. Great Britain :Stockton Press 1994:342\u20133."},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075049"},{"issue":"5","key":"e_1_2_5_21_2","first-page":"462","article-title":"Autoantibodies in pernicious anemia type I patients recognize sequence 251\u2013256 in human intrinsic factor","volume":"109","author":"Gueant JL","year":"1997","journal-title":"Proc Assoc Am Physicians"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70194-X"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1610-0387.2006.06087.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1610-0387.2006.06087.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T14:03:53Z","timestamp":1697033033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1610-0387.2006.06087.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,19]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1610-0387.2006.06087.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1610-0387.2006.06087.x","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,19]]}}}