{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:22:30Z","timestamp":1773008550481,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:italic>Background<\/jats:italic>: IgA pemphigus is a rare pustular autoimmune disease with exclusive IgA anti\u2010keratinocyte cell surface antibody reactivity. Two subtypes have been discerned: in the subcorneal pustular dermatosis type, desmocollin 1 has been identified as a targeted autoantigen, while in few cases of the intraepidermal neutrophilic type, IgA anti\u2010desmoglein 1 or IgA anti\u2010desmoglein 3 reactivity has been demonstrated.<\/jats:p><jats:p> <jats:italic>Patients and Methods<\/jats:italic>: A 48\u2010year\u2010old white male presented with generalized large confluent pustules. Skin pathology was assessed by histology and direct immunofluorescence analysis. IgG\/IgA autoantibodies against desmoglein 1\/3 and desmocollin 1 were measured by ELISA and indirect immunofluorescence using desmocollin 1 cDNA\u2010transfected COS7 cells, respectively.<\/jats:p><jats:p> <jats:italic>Results<\/jats:italic>: Histopathology revealed subcorneal pustules and direct immunofluorescence microscopy exclusively showed <jats:italic>in vivo<\/jats:italic> bound IgA with an intercellular pattern in the epidermis. Desmocollin 1 was identified as a target of IgA autoantibodies by indirect immunofluorescence microscopy utilizing desmocollin 1 cDNA\u2010transfected COS7 cells. In addition, IgA anti\u2010desmoglein 1 reactivity was demonstrated by ELISA. Neither IgA anti\u2010desmoglein 3 nor IgG anti\u2010desmoglein 1\/3 autoantibodies were present.<\/jats:p><jats:p> <jats:italic>Conclusions<\/jats:italic>: Both desmocollin 1 and desmoglein 1 were autoantigens in this patient with IgA pemphigus and a distinct clinical presentation. To our knowledge, this is the first IgA pemphigus case with dual autoantibody reactivity.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2006.06166.x","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T10:59:23Z","timestamp":1164625163000},"page":"1045-1050","source":"Crossref","is-referenced-by-count":19,"title":["IgA pemphigus \u2013 Occurrence of anti\u2010Desmocollin 1 and anti\u2010Desmoglein 1 antibody reactivity in an individual patient"],"prefix":"10.1111","volume":"4","author":[{"given":"Tamara","family":"Kopp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassian","family":"Sitaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Pieczkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Schneeberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"F\u00f6dinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Stingl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz M.","family":"Karlhofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70145-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1991.tb00413.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00193-0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb00344.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03604.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01061.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12319025"},{"key":"e_1_2_6_9_2","first-page":"735","article-title":"Detection of IgA autoantibodies to desmogleins by an enzyme\u2010linked immunosorbent assay: 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