{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:46:43Z","timestamp":1743961603289},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T00:00:00Z","timestamp":1174262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In October 2003 the German network of excellence \u201cEpidermolysis bullosa: molecular pathomechanisms and novel therapeutic approaches\u201c initiated its activities. The network partners are physicians and scientists working on epidermolysis bullosa (EB), basement membranes and structural proteins. The clinical partners and associated specialists improve interdisciplinary management of patients with EB and coordinate diagnostic and therapeutic procedures. Efficient molecular diagnostics consisting of antigen mapping and mutation analysis is offered in specialized centers. Using a highly productive information technology infrastructure, a central internet\u2010based patient registry contains clinical,genetic and molecular data.The registry provides a platform for genotype\u2010phenotype studies, epidemiological investigations, and for the identification of patients for future molecular therapies. Mouse models of different EB subtypes help elucidate causal disease mechanisms. Further scientific projects aim at understanding the normal mechanisms of epidermal adhesion to basement membranes, and protein\u2010protein\u2010 and cell\u2010ligand interactions, and their physiological regulation. These results will provide a foundation for developing novel therapeutic approaches for the causal treatment of EB.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2006.06181.x","type":"journal-article","created":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T11:15:24Z","timestamp":1174302924000},"page":"274-279","source":"Crossref","is-referenced-by-count":8,"title":["Network epidermolysis bullosa: molecular pathomechanisms and novel therapeutic approaches"],"prefix":"10.1111","volume":"5","author":[{"given":"Andreas","family":"Volz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Has","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hauke","family":"Schumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Bruckner\u2010Tuderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,19]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.106369"},{"key":"e_1_2_10_3_2","first-page":"920","article-title":"[Hereditary blistering disorders]","volume":"55","author":"Has C","year":"2004","journal-title":"Hautarzt"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1235.x"},{"key":"e_1_2_10_5_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2340\/00015555645762","article-title":"Occurrence of epidermolysis bullosa in Finland","volume":"64","author":"Kero M","year":"1984","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01130.x"},{"key":"e_1_2_10_7_2","first-page":"190","article-title":"An XML\u2010based remote data entry solution in a multi\u2010centric research network","volume":"3","author":"Klein A","year":"2005","journal-title":"J Qual Life Res"},{"key":"e_1_2_10_8_2","first-page":"125","article-title":"Building a Communications Infrastructure for a Multi\u2010Centric Research Network","volume":"2","author":"Ganslandt T","year":"2004","journal-title":"J Qual Life Res"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1610-0387.2006.06181.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1610-0387.2006.06181.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:26:59Z","timestamp":1697074019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1610-0387.2006.06181.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,19]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1111\/j.1610-0387.2006.06181.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1610-0387.2006.06181.x","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,19]]}}}