{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:01:29Z","timestamp":1757700089455},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T00:00:00Z","timestamp":1180483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A 50\u2010year\u2010old patient presented with erythema, vesicles and pustules as well as interphalangeal joint pain. Acrodermatitis continua suppurativa Hallopeau was diagnosed. She was treated topically with glucocorticos\u2010teroids, calcitriol, calcipotriol, tacrolimus and bath\u2010PUVA therapy without any clear benefit. Systemic acitretin 0.75 mg\/kg daily led to improvement but complete resolution could never be achieved.Because of acitretin\u2010induced mucosal side effects and hair loss, the dose was reduced to 20 mg\/d alternating with 10 mg\/d. The disease flared again. Additional therapy with etanercept 2 x 25 mg subcutaneously weekly was started. Within four weeks all symptoms resolved. The joint pain disappeared and the nail growth improved. After six months, etanercept therapy was discontinued. Two weeks later the first rebound of pustules occurred. Etanercept was restarted and the patient cleared rapidly. Etanercept therapy can be a useful therapeutic approach in refractory acrodermatitis continua suppurativa Hallopeau.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2007.06332.x","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T11:09:30Z","timestamp":1180523370000},"page":"489-492","source":"Crossref","is-referenced-by-count":15,"title":["Successful etanercept therapy in therapy refractory acrodermatitis continua suppurativa Hallopeau"],"prefix":"10.1111","volume":"5","author":[{"given":"Elke","family":"Weisshaar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Diepgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00811.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050668"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05992.x"},{"key":"e_1_2_6_5_2","first-page":"344","article-title":"Acitretin monotherapy in acrodermatitis continua Hallopeau","volume":"69","author":"Van Dooren\u2010Greebe RJ","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_6_2","first-page":"988","article-title":"Recommendations for the use of etanercept in psoriasis: a European dermatology expert group consensus","volume":"20","author":"Boehncke W\u2010H","year":"2006","journal-title":"JEADV"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-005-1006-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05761.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06759.x"},{"key":"e_1_2_6_10_2","first-page":"360","article-title":"The successful use of etanercept in combination therapy for treatment of acrodermatitis continua of Hallopeau","volume":"4","author":"Kazinski K","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_11_2","first-page":"705","article-title":"Etanercept and recalcitrant acrodermatitis continua of Hallopeau","volume":"5","author":"Nikkels AF","year":"2006","journal-title":"J Drugs Dermatol"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1610-0387.2007.06332.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1610-0387.2007.06332.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:53:29Z","timestamp":1697424809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1610-0387.2007.06332.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,30]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1111\/j.1610-0387.2007.06332.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1610-0387.2007.06332.x","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,30]]}}}