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Itraconazole accumulates in the stratum corneum and in nail material due to its high affinity to keratin, as well as in sebum and vaginal mucosa. Together with terbinafine and fluconazole, itraconazole belongs to the modern highly effective systemic antifungal drugs with a favorable risk\u2010benefit ratio and for this reason is a preferred therapy option for fungal infections of skin, nails and mucous membranes. Compared to terbinafine in the treatment of fingernail and toenail fungal infections, itraconazole offers the advantage of a broad antifungal spectrum and better effectiveness against onychomycosis caused by yeasts yet appears inferior with regard to the more common dermatophyte infections. Itraconazole constitutes an important therapy option, along with fluconazole, terbinafine, ketoconazole and griseofulvin, for the treatment of dermatophyte infections of glabrous skin (tinea pedis, tinea manuum, tinea corporis and tinea cruris) in adults following unsuccessful topical therapy. In the oral therapy of tinea capitis, itraconazole plays an especially important role, in particular for disease caused by <jats:italic>Microsporum canis<\/jats:italic> (for children, however, only off\u2010label use is feasible currently). In the treatment of oropharyngeal candidiasis, candidiasis of the skin and vulvovaginal candidiasis, itraconazole and fluconazole are the preferred treatment options in cases in which topical therapy has proven unsuccessful.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2008.06751.x","type":"journal-article","created":{"date-parts":[[2008,5,8]],"date-time":"2008-05-08T12:40:12Z","timestamp":1210250412000},"page":"11-19","source":"Crossref","is-referenced-by-count":19,"title":["The significance of itraconazole for treatment of fungal infections of skin, nails and mucous membranes"],"prefix":"10.1111","volume":"7","author":[{"given":"Hans Christian","family":"Korting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sch\u00f6llmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,24]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199958020-00005"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199651040-00006"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780410001731583"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200022010-00004"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.16619"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1989.tb02296.x"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01716289"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.10.2053"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70037-7"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.216-223.2004"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70026-E"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70102-L"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2003.00952.x"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-9959(99)00054-9"},{"key":"e_1_2_13_16_2","unstructured":"FDA Public Health Advisory.The safety of Sporanox capsules and Lamisil tablets for the treatment of onychomycosis verf\u00fcgbar unterhttp:\/\/www.fda.gov\/cder\/drug\/advisory\/sporanox\u2010lamisil\/advisory.htm."},{"key":"e_1_2_13_17_2","first-page":"72","article-title":"Klinisch wichtige Interaktionen vonAntimykotika","volume":"23","author":"K\u00e4mmerer W","year":"2005","journal-title":"Arzneimitteltherapie"},{"key":"e_1_2_13_18_2","first-page":"136","volume-title":"Derma\u2010tologische Qualit\u00e4tssicherung. 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