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The skin lesions, yellowish papules which coalesce into plaques of inelastic and leathery skin, demonstrate by histopathologic and ultrastructural examinations ectopic mineralization of dermal connective tissues, primarily the elastic structures. PXE is inherited in an autosomal recessive fashion due to mutations in the <jats:italic>ABCC6<\/jats:italic> gene. Significant insights into the pathogenesis of PXE have been recently obtained from observations on the <jats:italic>Abcc6<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> knockout mouse which mimics the genetic, histopathologic and ultrastructural features of PXE. This mouse model has provided a platform to test various treatment modalities to counteract the mineralization phenotypes. One of the intriguing findings emanating from these studies is that supplementation of the mouse diet with magnesium, at levels that are \u223c5\u2010fold higher than those in control diet, completely inhibits the development of tissue mineralization. These and related observations suggest that changes in the diet might counteract the progression of PXE and improve the quality of life of patients with this, currently intractable, disease.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2011.07658.x","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T06:42:30Z","timestamp":1300257750000},"page":"586-593","source":"Crossref","is-referenced-by-count":3,"title":["Pseudoxanthoma elasticum, the paradigm of heritable ectopic mineralization disorders \u2013 can diet 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