{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:29:30Z","timestamp":1762079370998},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T00:00:00Z","timestamp":1346371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Monotherapy with TNF\u2010\u03b1 inhibitors does not always produce a sufficient response in psoriasis patients. Combinations of TNF\u2010\u03b1 antagonists such as adalimumab with systemic antipsoriatic therapies such as methotrexate are not approved for use in psoriasis, and the published data are scarce.<\/jats:p><jats:p><jats:italic>Patients and methods<\/jats:italic>: The charts of 39 psoriasis patients from 6 dermatology departments were reviewed retrospectively. All patients were given adalimumbab with another systemic antipsoriatic drug.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Combination therapy with methotrexate was most common (n = 32), followed by acitretin (n = 4) and cyclosporine (n = 3). Combination therapy with methotrexate lasted 10.8 \u00b1 11.2 months (mean), with cyclosporine for 6.8 \u00b1 3.3 months, and with acitretin 12.9 \u00b1 12.4 months. Combinations were effective in the majority of patients: 30\/39 (76.9 %) had a good (n = 9) or excellent (n = 21) response. Two patients had a moderate response and 7 patients had a poor response and were switched to another treatment. Overall, safety was very good. Eighteen patients experienced 24 adverse events; none was severe and\/or required hospitalization. Of these, 10\/24 adverse events were infections, most often infections of the upper respiratory tract (n = 5), bronchitis (n = 2), and influenza (n = 1).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: Combinations of adalimumab with traditional systemic antipsoriatic treatments offer a promising method for managing severe or recalcitrant psoriasis. More data are needed to determine the long\u2010term safety and efficacy of these combinations.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2012.07976.x","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T09:05:06Z","timestamp":1346403906000},"page":"821-837","source":"Crossref","is-referenced-by-count":10,"title":["Combination of adalimumab with traditional systemic antipsoriatic drugs \u2013 a report of 39 cases"],"prefix":"10.1111","volume":"10","author":[{"given":"Sandra","family":"Philipp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Wilsmann\u2010Theis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar","family":"Weyergraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Rotterdam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Frambach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Gerdes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rotraut","family":"M\u00f6ssner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2010.03.003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03389.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.065615"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","unstructured":"DriessenRJ van de KerkhofPC de JongEM.Etanercept combined with methotrexate for high\u2010need psoriasis.2008;159(2):460\u20133.","DOI":"10.1111\/j.1365-2133.2008.08669.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0511"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.031"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.18"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.5414\/CPP47038"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12040.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22864"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.138"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.11.1043"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.119446"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.056"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630500482928"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03470.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08564.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)01587-1"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1610-0387.2012.07976.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1610-0387.2012.07976.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:13:54Z","timestamp":1697415234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1610-0387.2012.07976.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,31]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1610-0387.2012.07976.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1610-0387.2012.07976.x","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,31]]}}}