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In the last 17 years, many of the underlying mechanisms of anti\u2010psoriatic action, such as a Th1\/Th2 shift, a suppression of important leukocyte adhesion molecules, the induction of pro\u2010apoptotic pathways in T\u2010cells and recently anti\u2010angiogenic action, have been discovered. Based on the knowledge of these immunomodulatory characteristics, fumaric acid esters have been shown to be effective or potentially effective in a multitude of dermatological as well as non\u2010dermatological diseases. The range of new therapeutic targets reaches from multiple sclerosis to illnesses such as necrobiosis lipoidica, granuloma annulare and sarcoidosis. Experimental approaches offer promising, although preliminary, results on the treatment of cancer, malaria, chronic inflammatory lung diseases, and Huntington disease, to name but a few. This valued and well\u2010known drug mainly prescribed by dermatologists is now experiencing a renaissance far beyond dermatologic applications.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2012.07996.x","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T09:19:10Z","timestamp":1345195150000},"page":"793-801","source":"Crossref","is-referenced-by-count":23,"title":["Dimethyl fumarate \u2013 only an anti\u2010psoriatic medication?"],"prefix":"10.1111","volume":"10","author":[{"given":"Markus","family":"Meissner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Maria","family":"Valesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kippenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,17]]},"reference":[{"key":"e_1_2_11_2_2","first-page":"103","article-title":"Behandlung der Psoriasis vulgaris","volume":"13","author":"Schweckendiek W","year":"1959","journal-title":"Med Monatsschr"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-4-22"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.197"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1061-4"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.07120.x"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017903"},{"key":"e_1_2_11_8_2","first-page":"79","article-title":"Fumaric acid esters (FAEs) suppress CD 15\u2010 and ODP 4\u2010positive cells in psoriasis","volume":"186","author":"Bacharach\u2010Buhles M","year":"1994","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.11.011"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100977"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1747.2003.12605.x"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260916"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07779.x"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04220.x"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02400.x"},{"key":"e_1_2_11_16_2","first-page":"29","article-title":"The antipsoriatic dimethyl\u2010fumarate suppresses interferon\u2010gamma \u2010induced ICAM\u20101 and HLA\u2010DR expression on hyperproliferative keratinocytes. 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