{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T04:31:59Z","timestamp":1697689919704},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> S\u00e9zary syndrome (SS) is defined by the triad of erythroderma, generalized lymphadenopathy and more than 1 000 circulating S\u00e9zary cells\/\u03bcl in the peripheral blood.<\/jats:p><jats:p><jats:bold>Patients and Methods:<\/jats:bold> We screened the cutaneous lymphoma registry of our department for SS patients to identify clinical features of SS besides the defining criteria and to correlate them with disease survival.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> 24 SS patients were analyzed retrospectively. The mean age was 65 years with 62 % male patients. The median follow\u2010up time was 32.5 months with an estimated 5\u2010year overall survival rate of 76 %. All patients complained about itching and presented with palmoplantar keratoderma. 62.5 % had nail involvement, 21 % alopecia, 12.5 % ectropion, 4 % prurigo nodularis, 8 % localized and 8 % generalized skin tumors, including leonine facies. In addition, 33 % had infections and also 33 % had venous thromboembolism. We identified cutaneous tumor cell load as a significant prognostic marker for SS. None of the other parameters were associated with disease specific survival.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Clinically SS is characterized by various presentations beyond erythroderma. The cutaneous tumor cell load in SS is strongly associated with outcome and survival. We demonstrate a high risk for venous thromboembolism in SS patients who might benefit from anti\u2010coagulation therapies.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2012.08027.x","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T20:11:08Z","timestamp":1353442268000},"page":"67-79","source":"Crossref","is-referenced-by-count":4,"title":["Cutaneous tumor cell load correlates with survival in patients with S\u00e9zary syndrome"],"prefix":"10.1111","volume":"11","author":[{"given":"Nina","family":"Booken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan 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