{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:59:57Z","timestamp":1781125197242,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> Chronic cholestatic pruritus (ChP) is caused by various hepatobiliary disorders. This retrospective study describes the distribution of underlying diseases, clinical characteristics and treatment efficacy in a consecutive collective of patients with ChP.<\/jats:p><jats:p><jats:bold>Patients and methods:<\/jats:bold> Extensive data from 60 patients with ChP (30 women, 30 men; mean age: 58.0 \u00b1 17.0 years) were retrospectively statistically analyzed concerning demographic data, pruritus characteristics, and response to therapy.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In this study population, 40.0% of the patients suffered from hepatitis B or C. Regarding the overall population, pruritus started in 50% of patients after diagnosis of the underlying hepatobiliary disorder. Only in patients with immune\u2010mediated liver diseases did pruritus more often occur before diagnosis (p &lt; 0.05). Only 23.3% of the patients reported an initial palmoplantar pruritus. Along with other drugs, anticonvulsants proved to be an effective treatment regime.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In this study, viral pathogenesis was the most common cause of ChP. Other underlying diseases were represented to a lower extent in the total study population. Overall, the collected clinical parameters in each group were comparable. Thus, it was difficult to draw conclusions on the pathogenesis.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2012.08028.x","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T16:21:39Z","timestamp":1354206099000},"page":"158-168","source":"Crossref","is-referenced-by-count":6,"title":["Cholestatic pruritus: a retrospective analysis on clinical characteristics and treatment response"],"prefix":"10.1111","volume":"11","author":[{"given":"Mario","family":"Huesmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Huesmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nani","family":"Osada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Quan","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas 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