{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:19:16Z","timestamp":1784920756580,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Background: Over the last years, growing resistance of gonorrhea to quinolones has emerged worldwide. Currently, cases with resistance to oral and parenteral third\u2010generation cephalosporins are increasingly reported. Because gonorrhea is not a notifiable infection in Germany, data on epidemiology and antimicrobial surveillance of gonorrhea are scarce. We present the results of<jats:italic>N. gonorrhoea<\/jats:italic>testing at the University Hospital Dresden over the course of ten years.<\/jats:p><jats:p>Patients and Methods: The results of cultural and nucleic acid amplification testing of gonorrhea and accompanying infections of 1,850 smears between 2001 and 2010 were analyzed retrospectively.<\/jats:p><jats:p>Results: Among 181 patients (mean age 30.4 years) 159 had positive PCR analyses for gonorrhea and 50 positive cultures of<jats:italic>Neisseria gonorrhoea<\/jats:italic>. The rate of ciprofloxacin resistance was high (in 46% of all isolates), primarily in men. Resistance to cefotaxime and ceftriaxone could not be detected so far. In 40% of the cases at least one accompanying urogenital infection occurred, predominantly with<jats:italic>Chlamydia trachomatis<\/jats:italic>.<\/jats:p><jats:p>Conclusions: Similar to other regions of Germany, a high percentage of resistance to quinolones was found in gonorrhea, but not to cephalosporins. Additionally, accompanying infections were frequent and warrant screening. In the light of recent cases of resistance to cephalosporins currently emerging in Europe, cultural diagnosis of gonorrhea should definitely be intensified by all means. The results should be integrated into a surveillance system.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2012.08044.x","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T18:49:40Z","timestamp":1354214980000},"page":"241-249","source":"Crossref","is-referenced-by-count":5,"title":["Gonorrhea: Data on antibiotic resistance and accompanying infections at the University Hospital Dresden over a 10\u2010year time period"],"prefix":"10.1111","volume":"11","author":[{"given":"Susanne","family":"Abraham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Poehlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Spornraft\u2010Ragaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"WHO sexually transmitted diseases:http:\/\/www.who.int.\/vaccine_research\/diseases\/soa_std\/en\/index2.html(accessed 9. Juli 2010 Nr. 2)."},{"key":"e_1_2_6_3_2","first-page":"182","article-title":"Genitale Neisseria gonorrhoeae\u2010Infektionen \u2013 aktuelle Aspekte zur Epidemiologie, Labordiagnostik, Resistenzsituation und Therapie","volume":"15","author":"Nenoff P","year":"2010","journal-title":"Gyn"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-11-200506070-00010"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.5.1751-1756.2001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-011-0169-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl265"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2010.044164"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01691501"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050051192"},{"key":"e_1_2_6_11_2","first-page":"35","article-title":"Stark zunehmende Resistenz von Neisseria gonorrhoeae gegen Ciprofloxacin in Norddeutschland","volume":"10","author":"Ungeheuer J","year":"2001","journal-title":"Chemother J"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-006-0134-y"},{"key":"e_1_2_6_13_2","unstructured":"Epidemiologisches Bulletin: Zum Auftreten von Resistenzen beiNeisseria gonorrhoeaeim Rhein\u2010Main\u2010Gebiet; 2009\/13;122\u20133."},{"key":"e_1_2_6_14_2","first-page":"28","article-title":"Update Gonorrhoe. Resistenzen nehmen weiter zu","volume":"60","author":"Nenoff P","year":"2012","journal-title":"Dt Dermatologe"},{"key":"e_1_2_6_15_2","first-page":"1","article-title":"Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"Workowski KA","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009160"},{"key":"e_1_2_6_17_2","first-page":"873","article-title":"Cephalosporin Susceptibility among Neisseria gonorrhoeae Isolates \u2013 United States, 2000\u20132010. CDC Morbidity and Mortality Weekly Report","volume":"60","year":"2011","journal-title":"MMWR"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1426-4"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr332"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3201\/eid1308.060948","article-title":"Threat to cefixime treatment for gonorrhea","volume":"13","author":"Yokoi S","year":"2007","journal-title":"Emerg Infect Dis."},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/430787"},{"issue":"14","key":"e_1_2_6_22_2","first-page":"pii: 19833","article-title":"Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010","volume":"16","author":"Ison CA","year":"2011","journal-title":"Euro Surveill"},{"issue":"47","key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"pii: 19721","DOI":"10.2807\/ese.15.47.19721-en","article-title":"Two cases of verified clinical failures using internationally recommended first\u2010line cefixime for gonorrhoea treatment, Norway, 2010","volume":"15","author":"Unemo M","year":"2010","journal-title":"Euro Surveill"},{"issue":"43","key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"pii: 19998","DOI":"10.2807\/ese.16.43.19998-en","article-title":"First Neisseria \u2028 gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011","volume":"16","author":"Unemo M","year":"2011","journal-title":"Euro Surveill"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00325-11"},{"issue":"6","key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"pii: 19792","DOI":"10.2807\/ese.16.06.19792-en","article-title":"Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010","volume":"16","author":"Unemo M","year":"2011","journal-title":"Euro Surveill"},{"key":"e_1_2_6_27_2","unstructured":"Epidemiologisches Bulletin: Sechs Jahre STD\u2010Sentinel\u2010Surveillance in Deutschland \u2013 Zahlen und Fakten 25.1.2010 Nr. 3 20\u201326."},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-2-200707170-00007"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/521266"},{"issue":"6","key":"e_1_2_6_30_2","first-page":"193","article-title":"Paul Ehrlich Society for Chemotherapy. [Rational use of oral antibiotics. Findings of an expert commission of the Paul Ehrlich Society for Chemotherapy]","volume":"25","author":"Vogel F","year":"2002","journal-title":"Med Monatsschr Pharm"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2011.011267"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1610-0387.2012.08044.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1610-0387.2012.08044.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:01:02Z","timestamp":1745366462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1610-0387.2012.08044.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,29]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/j.1610-0387.2012.08044.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1610-0387.2012.08044.x","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,29]]}}}