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We report on two new cases of PNH with novel clinical symptoms. In the first case, the patient had microcytic anemia due to massive iron deposition in the nodules and a progressively worsening limp due to involvement of the soles. The complex therapeutic challenge was effectively managed by successive surgical ablation of all visible lesions. The second patient had epibulbar infiltrates. The clinical variability of PNH leads to considerable overlap with other forms of NLCH.<\/jats:p>","DOI":"10.1111\/j.1610-0387.2012.08069.x","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T15:33:49Z","timestamp":1355240029000},"page":"301-307","source":"Crossref","is-referenced-by-count":6,"title":["Progressive nodular histiocytosis"],"prefix":"10.1111","volume":"11","author":[{"given":"Olaf","family":"Hilker","sequence":"first","affiliation":[{"name":"Helios Klinikum Wuppertal, Department of Dermatology Allergology, and Surgical Dermatology  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kovneristy","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Dermatology and Allergology University of Munich  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Varga","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Dermatology and Allergology University of Munich  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Neubert","sequence":"additional","affiliation":[{"name":"Helios Klinikum Wuppertal, Department of Dermatology Allergology, and Surgical Dermatology  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Wesselmann","sequence":"additional","affiliation":[{"name":"Helios Klinikum Wuppertal, Department of Dermatology Allergology, and Surgical Dermatology  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Flaig","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Dermatology and Allergology University of Munich  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ruzicka","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Dermatology and Allergology University of Munich  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Burgdorf","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Dermatology and Allergology University of Munich  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Percy","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Helios Klinikum Wuppertal, Department of Dermatology Allergology, and Surgical Dermatology  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1001\/archderm.1978.01640220054014","article-title":"Progressive nodular histiocytoma","volume":"114","author":"Taunton OD","year":"1978","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_3_1","volume-title":"WHO Classification of Tumours of Haemotopoetic and Lymphoid Tissues","author":"Jaffe 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