{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:33:33Z","timestamp":1790177613676,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T00:00:00Z","timestamp":1174521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aim: The purpose of this study is to evaluate echocardiographically determined cardiac functions with serum levels of brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and total antioxidant status (TAOS) in childhood leukemia treated with chemotherapeutics containing anthracyclines.<\/jats:p><jats:p>Methods: A study group of 29 patients who have been followed for acute lymphoblastic leukemia (ALL) and administered a treatment protocol containing chemotherapy of anthracyclines were included in the analysis. Levels of BNP, cTnI and TAOS were studied in serum samples of the patients.<\/jats:p><jats:p>Results: We demonstrated that as the drug dosage increased, systolic ejection fraction (EF) and shortening fraction (FS) values decreased (EF r<jats:sup>2<\/jats:sup>= 0.2327, FS r<jats:sup>2<\/jats:sup>= 0.251). On the other hand, increased dosage of anthracycline therapy was associated with significant raise in plasma BNP levels (r<jats:sup>2<\/jats:sup>= 0.246) and significant decrease in serum TAOS levels (r<jats:sup>2<\/jats:sup>= 0.317) without any change in serum cTnI levels.<\/jats:p><jats:p>Conclusion: Our study suggest that serum TAOS and BNP levels may be useful as an early and sensitive indicator of anthracycline induced cardiotoxicity.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2006.00174.x","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T20:57:20Z","timestamp":1209589040000},"page":"506-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Early prediction of anthracycline induced 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