{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:41:17Z","timestamp":1697434877471},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T00:00:00Z","timestamp":1190332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aim: To investigate bilirubin UDP\u2010glucuronosyltransferase (<jats:italic>UGT1A1<\/jats:italic>) gene allele in healthy Chinese neonates, their cord bilirubin level and the subsequent hyperbilirubinemia to determine relationships among them.<\/jats:p><jats:p>Methods: Cord blood of 48 neonates was obtained to determine the exon 1 of <jats:italic>UGT1A1<\/jats:italic> gene, total serum bilirubin, albumin, glutamic\u2010pyruvic transaminase (GPT), glutamic\u2010oxalacetic transaminase (GOT) and haemoglobin (Hb) concentration. Neonatal jaundice was assessed by measurement of transcutaneous bilirubin (TCB) and serum bilirubin. Neonates were divided into two groups according to mutant or normal allele to compare the variables.<\/jats:p><jats:p>Results: Nineteen infants had the nucleotide 211 G\u2192A allele, 3 had the heterozygous variation (686C\u2192A, 845 A\u2192T, 231G\u2192A). In the 211 A allele group, cord bilirubin was significantly higher than in the 211 G allele group (p = 0.034), but there were no differences in albumin (p = 0.678), GPT (p = 0.460), GOT <jats:italic>(<\/jats:italic>p = 0.440) and Hb (p = 0.886). The TCB (at 48, 96 h), the frequency of the hyperbilirubinemia and prolonged jaundice were also significantly higher in the 211 A allele group.<\/jats:p><jats:p>Conclusions: The <jats:italic>UGT1A1<\/jats:italic> gene codon G71R allele is a risk factor for neonatal hyperbilirubinemia in the Chinese population. Its effect on bilirubin metabolism may present early on, as well as late in foetal life.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2007.00501.x","type":"journal-article","created":{"date-parts":[[2007,9,22]],"date-time":"2007-09-22T07:12:32Z","timestamp":1190445152000},"page":"1622-1625","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cord blood bilirubin level in relation to bilirubin UDP\u2010glucuronosyltransferase gene missense allele in Chinese 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