{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:28:42Z","timestamp":1705588122511},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T00:00:00Z","timestamp":1193702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aim: Ulcerative Colitis (UC) has an incidence of 1.4 per 100 000 in childhood. There is a paucity of data regarding outcome particularly with the increased use of early immunosuppression. This study reviews outcome at 2 years in a cohort with UC referred to a single centre.<\/jats:p><jats:p>Method: Patients were recruited on the basis of a diagnosis made between 2000 and 2003 as a consecutive cohort. All had UC according to standard clinicopathological criteria. Children with indeterminate colitis were excluded. Follow\u2010up data was collected at 2 years by case notes review.<\/jats:p><jats:p>Results: Thirty\u2010two children are reported. The median age at diagnosis was 11 years (range 2\u201316). All were treated with corticosteroids and 5\u2010ASA derivatives at diagnosis. The majority of patients (94%, 30\/32) received more than one course of steroids. By 2 years azathioprine use was high with 75% (24\/32) of patients on treatment for steroid\u2010dependent disease. There were 6 extra\u2010intestinal manifestations and 8 disease related complications occurring in 12 patients (38%). The colectomy rate was 9% (3\/32) for unresponsive disease.<\/jats:p><jats:p>Conclusion: There is a high need for Azathioprine in childhood UC. Colectomy rate at 2 years was around 10%. Extra\u2010intestinal manifestations and disease related complications are common.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2007.00515.x","type":"journal-article","created":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T17:05:59Z","timestamp":1193763959000},"page":"1790-1793","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Outcome of childhood ulcerative colitis at 2 years"],"prefix":"10.1111","volume":"96","author":[{"given":"LJ","family":"Howarth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AE","family":"Wiskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DM","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NA","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RM","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04309-9"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.1.37"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70193-2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(00)80057-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.080481"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043372"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000163736.30261.82"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.1.29"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7563.340"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200301000-00006"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.078055"},{"key":"e_1_2_5_13_2","first-page":"592","article-title":"The importance of early surgery\u2003in children with ulcerative colitis","volume":"2","author":"Nagar H","year":"2000","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i10.2300"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2007.00515.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2007.00515.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:09:37Z","timestamp":1697425777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2007.00515.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1651-2227.2007.00515.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2007.00515.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,12]]},"assertion":[{"value":"2007-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}