{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T07:59:35Z","timestamp":1719993575531},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,3]],"date-time":"2008-01-03T00:00:00Z","timestamp":1199318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aim: To investigate circulating leptin levels in biliary atresia (BA) patients and the association of leptin with bone mineral density (BMD) and the severity of BA.<\/jats:p><jats:p>Methods: We have examined 50 patients with BA and 15 matched healthy controls. Serum leptin, osteocalcin and C\u2010terminal telopeptide of type I collagen (CTX) levels were measured by sandwich enzyme\u2010linked immunosorbent assay (ELISA). BMD of the lumbar spine was measured by dual energy X\u2010ray absorptiometry.<\/jats:p><jats:p>Results: Serum leptin levels of BA patients were lower than those of healthy controls (2.7 \u00b1 0.3 vs. 7.1 \u00b1 1.7 ng\/mL, p = 0.0001). Among the BA patients, serum leptin levels were significantly lower in patients with jaundice than patients without jaundice (1.7 \u00b1 0.2 vs. 3.4 \u00b1 0.4 ng\/mL, p = 0.001). BMD of BA patients was correlated (p &lt; 0.001) with leptin levels, age and BMI (r = 0.55, r = 0.75 and r = 0.58, respectively). The serum CTX levels were significantly higher in jaundice patients compared with jaundice\u2010free patients and the healthy controls (0.6 \u00b1 0.2 vs. 0.2 \u00b1 0.1 ng\/mL, p = 0.01), whereas the serum osteocalcin levels in BA patients were not different from those in the controls.<\/jats:p><jats:p>Conclusion: Circulating leptin levels are correlated with BMD and the presence of jaundice in BA, suggesting that the leptin may play a physiological role in maintaining bone mass of BA patients with jaundice.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2007.00596.x","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T14:33:11Z","timestamp":1201703591000},"page":"206-211","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Circulating leptin levels and bone mineral density in children with biliary atresia"],"prefix":"10.1111","volume":"97","author":[{"given":"Sittisak","family":"Honsawek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tawatchai","family":"Chaiwatanarat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Voranush","family":"Chongsrisawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nutchanart","family":"Thawornsuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paisarn","family":"Vejchapipat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Poovorawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)63625-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1996.01430170039006"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80243-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200206150-00015"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1542\/peds.91.6.1151","article-title":"Bone mineral content in infants and children with chronic cholestatic liver disease","volume":"91","author":"Argao EA","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117959"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7063.953"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290038"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005830"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92506-6"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.12.4702"},{"key":"e_1_2_6_15_2","first-page":"195","volume-title":"Liver Disease in Children","author":"Feranchak AP","year":"2001"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003830100003"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318030ac0e"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0363-6"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225513.20913.6a"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02746.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1054"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200x.2005.02083.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00448.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(01)00107-3"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80156-7"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80157-9"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00448.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70267-7"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800768"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290601"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979882"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)39018-6"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.3928\/0090-4481-19950601-07"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10334"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2007.00596.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2007.00596.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T14:37:06Z","timestamp":1697380626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2007.00596.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1651-2227.2007.00596.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2007.00596.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,3]]},"assertion":[{"value":"2008-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}