{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:51:29Z","timestamp":1767851489345,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,2,14]],"date-time":"2011-02-14T00:00:00Z","timestamp":1297641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>41XXY mouse models share many characteristics of the human 47XXY Klinefelter syndrome (KS). This manuscript discusses the relative role of androgen deficiency and X chromosome genes resulting in the XXY mouse phenotype. The similarities in phenotype between 47XXY men and 41XXY mice suggest that the clinical manifestations in XXY men may be because of gene\u2010dosage effect from genes that escape X inactivation in mouse.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>The 41XXY mouse is an excellent model for KS.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02149.x","type":"journal-article","created":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T20:30:20Z","timestamp":1294864220000},"page":"892-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mouse model for men with klinefelter syndrome: a multifaceted fit for a complex disorder"],"prefix":"10.1111","volume":"100","author":[{"given":"Ronald S","family":"Swerdloff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YanHe","family":"Lue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Y","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Erkkil\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,14]]},"reference":[{"key":"e_1_2_13_2_2","first-page":"460","article-title":"Klinefelter syndrome: expanding the phenotype and identifying new research directions","volume":"5","author":"Simpson JL","year":"2003","journal-title":"GenetMed."},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16678-6"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201956"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0278"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.4.8086"},{"key":"e_1_2_13_7_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1365-2605.2009.00979.x","article-title":"Transplanted XY germ cells produce spermatozoa in testes of XXY mice*","volume":"33","author":"Lue Y","year":"2009","journal-title":"Int J Androl."},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00085.2010"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.104"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2795(199802)49:2<101::AID-MRD1>3.0.CO;2-T"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3120"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00360527"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaq024"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1396"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.08.007"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1892"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9160"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10735"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1596"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.84"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2005.09.011"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.11.6.738"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1983.tb00885.x"},{"key":"e_1_2_13_24_2","first-page":"E914","article-title":"Effects of estrogen on free fatty acid metabolism in humans","volume":"266","author":"Jensen MD","year":"1994","journal-title":"Am J Physiol."},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.08.001"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1375"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03440"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03479"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.103200.109"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000133152"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14180"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14440"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2011.02149.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2011.02149.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:08:07Z","timestamp":1712102887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2011.02149.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,14]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1651-2227.2011.02149.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2011.02149.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,14]]},"assertion":[{"value":"2011-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}