{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:13:18Z","timestamp":1790629998448,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims:\u2002<\/jats:bold> To investigate risk factors for metabolic syndrome in prepubertal boys with Klinefelter syndrome.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Eighty\u2010nine boys with Klinefelter syndrome, ages 4\u201312.9\u2003years, and 34 age\u2010matched control boys had height, weight, waist circumference and blood pressure measured and their parents completed a questionnaire about physical activity. The boys with Klinefelter syndrome also had measurement of lipids, fasting glucose and insulin. Insulin\u2010glucose homeostasis model assessment was calculated, and the boys were evaluated for childhood metabolic syndrome.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The Klinefelter syndrome and control groups were similar ages (7.5\u2003\u00b1\u20032.4 vs. 8.1\u2003\u00b1\u20032.3\u2003years). Body mass index measurements were similar, but waist circumference was &gt;90 percentile in 30% of boys with Klinefelter syndrome versus 21% of controls. The mean daily time spent running was 42\u2003min less in the Klinefelter syndrome versus control groups (p\u2003&lt;\u20030.01). About 37% of the boys with Klinefelter syndrome had elevated LDL cholesterol, 24% had insulin resistance, and 7% met the three criteria for diagnosis of metabolic syndrome.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Truncal obesity, insulin resistance and metabolic syndrome are present in boys as young as 4\u201312\u2003years with Klinefelter syndrome, and these occur in association with reduced running\u2010type activity.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02161.x","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T16:04:34Z","timestamp":1295453074000},"page":"866-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Insulin resistance and metabolic syndrome in prepubertal boys with Klinefelter syndrome"],"prefix":"10.1111","volume":"100","author":[{"given":"Martha 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