{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:21:53Z","timestamp":1791937313124,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T00:00:00Z","timestamp":1298592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To compare risk\u2010adjusted outcomes at 18\u2010 to 22\u2010month\u2010corrected age for extremely low birth weight (ELBW) infants who never received phototherapy (NoPTx) to those who received any phototherapy (PTx) in the NICHD Neonatal Research Network randomized trial of Aggressive vs. Conservative Phototherapy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Outcomes at 18 to 22\u2010month\u2010corrected age included death, neurodevelopmental impairment (NDI) and Bayley Scales Mental Developmental Index (MDI). Regression models evaluated the independent association of PTx with adverse outcomes controlling for centre and other potentially confounding variables.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of 1972 infants, 216 were NoPTx and 1756 were PTx. For the entire 501\u2010 to 1000\u2010g\u2010BW cohort, PTx was not independently associated with death or NDI (OR 0.85, 95% CI: 0.60\u20131.20), death or adverse neurodevelopmental endpoints. However, among infants 501\u2013750\u2003g BW, the rate of significant developmental impairment with MDI\u2003&lt;\u200350 was significantly higher for NoPTx (29%) than PTx (12%) (p\u2003=\u20030.004).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Phototherapy did not appear to be independently associated with death or NDI for the overall ELBW group. Whether PTx increases mortality could not be excluded because of bias from deaths before reaching conservative treatment threshold. The higher rate of MDI\u2003&lt;\u200350 in the 501\u2010 to 750\u2010g\u2010BW NoPTx group is concerning and consistent with NRN Trial results.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02175.x","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T18:53:27Z","timestamp":1296154407000},"page":"960-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Is phototherapy exposure associated with better or worse outcomes in 501\u2010 to 1000\u2010g\u2010birth\u2010weight infants?"],"prefix":"10.1111","volume":"100","author":[{"given":"Susan R","family":"Hintz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisa P","family":"Van Meurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda H","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon E","family":"Tyson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Kenneth","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale L","family":"Phelps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia E","family":"McDavid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Grisby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary D","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (see Acknowledgements in Supporting Information, Data S1)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1542\/peds.75.2.393","article-title":"Efficacy of phototherapy in prevention of neonatal hyperbilirubinemia","volume":"75","author":"Brown AK","year":"1985","journal-title":"Pediatrics"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1542\/peds.75.2.422","article-title":"Neonatal and infant mortality in relation to phototherapy","volume":"75","author":"Lipsitz PJ","year":"1985","journal-title":"Pediatrics"},{"key":"e_1_2_6_4_2","volume-title":"Effective care of the newborn infant","author":"Maisels MJ","year":"1992"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1999.tb00199.x"},{"key":"e_1_2_6_6_2","first-page":"376","article-title":"Associated of PDA and phototherapy in infants weighing less than 1000 grams","author":"Barefield ES","year":"1993","journal-title":"J Perinatol"},{"key":"e_1_2_6_7_2","first-page":"593","article-title":"Phototherapy and PDA","volume":"80","author":"Scheidt PC","year":"1987","journal-title":"Pediatrics"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.44.3.499"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/08035250600771458"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000243124"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000242190"},{"key":"e_1_2_6_12_2","first-page":"381","article-title":"Role of oxidative stress as physiopathologic factor in the preterm infant","volume":"56","author":"Dani C","year":"2004","journal-title":"Minerva Pediatr"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(02)00194-X"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1542\/peds.83.6.915","article-title":"Hyperbilirubinemia in preterm infants and neurodevelopmental outcome at 2\u2003years of age: results of a national collaborative survey","volume":"83","author":"Van de Bor M","year":"1989","journal-title":"Pediatrics"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.7.725"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.4.773"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01688.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803024"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.09.014"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.046268"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2247"},{"key":"e_1_2_6_22_2","volume-title":"Bayley scales of infant development II","author":"Bayley N","year":"1993"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181a7be77"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2004.09.003"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0492"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.199"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2011.02175.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2011.02175.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:28:06Z","timestamp":1697441286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2011.02175.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,25]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1111\/j.1651-2227.2011.02175.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2011.02175.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,25]]},"assertion":[{"value":"2011-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}