{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:31:56Z","timestamp":1782311516956,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T00:00:00Z","timestamp":1299456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To review the evidence base for providing testosterone therapy in the infant and prepubertal child with Klinefelter syndrome (KS).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Major databases were searched to identify articles that addressed the role of testosterone in the development of the male foetus with and without KS and that characterized testicular function in infants with KS.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Infants with KS have been shown to have an increased frequency of clinical features consistent with deficient testosterone production. However, there are conflicting results regarding whether testosterone levels are low or normal. No direct data address the outcome of therapy in the prepubertal child.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> There is an absence of data that directly address the risks and benefits of testosterone therapy in prepubertal children with KS outside of the entity of microphallus. At this time, there is no other documented benefit for testosterone therapy in these children.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02184.x","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T15:34:00Z","timestamp":1296574440000},"page":"846-850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Testosterone and the child (0\u201312\u2003years) with Klinefelter syndrome (47XXY): a review"],"prefix":"10.1111","volume":"100","author":[{"given":"Ilene","family":"Fennoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,7]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.8.3281"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2009.03.011"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02554.x"},{"key":"e_1_2_8_5_2","first-page":"59","article-title":"The anti\u2010Mullerian hormone","volume":"13","author":"Josso N","year":"1977","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod22.1.9"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.668"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92560-1"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1980.02130150050013"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70244-1"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02066"},{"key":"e_1_2_8_12_2","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1210\/jcem.85.12.7058","article-title":"A possible role for reproductive hormones in newborn boys: progressive hypogonadism without the postnatal testosterone peak","volume":"85","author":"Main KM","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087313"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02977.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(82)80008-X"},{"key":"e_1_2_8_16_2","first-page":"432","article-title":"[Klinefelter syndrome in 1993. Results of a multicenter study on 58 cases and review of the literature]","volume":"40","author":"Battin J","year":"1993","journal-title":"Ann Pediatr (Paris)"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000282218"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.10.019"},{"key":"e_1_2_8_19_2","first-page":"203","volume-title":"Sex chromosome aneuploidy: prospective studies in children","author":"Robinson A","year":"1979"},{"key":"e_1_2_8_20_2","first-page":"7","article-title":"Sex chromosomal abnormalities (SCA): a prospective and longitudinal study of newborns identified in an unbiased manner","volume":"18","author":"Robinson A","year":"1982","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_8_21_2","first-page":"73","article-title":"Edinburgh study of growth and development of children with sex chromosome abnormalities. III","volume":"22","author":"Ratcliffe SG","year":"1986","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031624"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0310"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107621"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1976.tb01985.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-42-4-679"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.034017"},{"key":"e_1_2_8_28_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.33549\/physiolres.930292","article-title":"Inhibin B, follicle stimulating hormone, luteinizing hormone and testosterone during childhood and puberty in males: changes in serum concentrations in relation to age and stage of puberty","volume":"52","author":"Chada M","year":"2003","journal-title":"Physiol Res"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198501000-00022"},{"key":"e_1_2_8_30_2","first-page":"23","article-title":"Sex chromosomal aneuploidy: prospective and longitudinal studies","volume":"22","author":"Robinson A","year":"1986","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.896"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92416-F"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi039"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)69099-2"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.05.019"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1982.03970390032010"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.22.2.191"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10154"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.04.016"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32232"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(92)90012-F"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(90)90297-P"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2007.09.001"},{"key":"e_1_2_8_44_2","first-page":"1","article-title":"Edinburgh study of growth and development of children with sex chromosome abnormalities. IV","volume":"26","author":"Ratcliffe SG","year":"1990","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.120675"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2011.02184.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2011.02184.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:54:34Z","timestamp":1697417674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2011.02184.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,7]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1651-2227.2011.02184.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2011.02184.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,7]]},"assertion":[{"value":"2011-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}