{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:23:45Z","timestamp":1791908625645,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T00:00:00Z","timestamp":1302220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To evaluate quality of life (QOL) in infants with atopic dermatitis (AD) by comparison with healthy infants to find treatment modalities contributing most to QOL in these patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The population (N\u2003=\u2003134) was recruited in the context of an on\u2010going prospective mother\u2013infant study. QOL was measured using the Infant Dermatitis Quality of Life Index for the infants with AD and a modification of this for the healthy infants.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The index scores of infants with AD were 4.15 (SD 2.96), 3.89 (SD 3.62) and 3.23 (SD 2.71) at 6, 12 and 24\u2003months, respectively, the QOL being significantly poorer at 6 (p\u2003&lt;\u20030.001) and 12 (p\u2003=\u20030.01) months compared to healthy infants. The principal impairments were itching, scratching and sleep disturbances at 6 and 12\u2003months and treatment difficulties at 6\u2003months. Problems with getting to sleep were reported at all stages irrespective of AD.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Simple treatment regimens targeting itching in particular are likely to contribute most to the QOL of infants with AD; however, sleeping problems may remain as an age\u2010related phenomenon. Early detection of symptoms and effective parent guidance contributed to the well\u2010being of the child.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02229.x","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T18:03:55Z","timestamp":1298397835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Quality of life in infants with atopic dermatitis and healthy infants: a follow\u2010up from birth to 24\u2003months"],"prefix":"10.1111","volume":"100","author":[{"given":"S","family":"Alanne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nermes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"S\u00f6derlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Laitinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,8]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70536-1"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2010.06.003"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra074081"},{"key":"e_1_2_8_5_2","unstructured":"World Health Organization.World Health Organization Constitution. 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