{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:19:06Z","timestamp":1697530746728},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T00:00:00Z","timestamp":1300924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> A 6\u2010month\u2010old infant with severe hyporegenerative anaemia, muscular hypotonia and developmental delay is reported, and the metabolic, diagnostic and therapeutic implications of this case are discussed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Diagnostic work\u2010up disclosed vitamin B12 depletion with an elevated excretion of methylmalonic acid (MMA), but a normal plasma total homocysteine. MRI showed fronto\u2010temporal atrophy and a delay in myelinization. The boy\u2019s disease was attributable to a maternal atrophic gastritis. After initiation of vitamin B12 supplementation, he quickly recovered regarding haematopoiesis and MMA excretion. His neurological development completely normalized during 18\u2003months of follow\u2010up including assessment by Bayley scores.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> As the majority of reported patients with this acquired form of methylmalonic aciduria show a persistent neurological deficit, early diagnosis of this condition is mandatory and should include sensitive markers of vitamin B12 depletion, namely MMA formation and plasma homocysteine.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02242.x","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T16:37:29Z","timestamp":1298738249000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intact recovery from early \u2018acquired methylmalonic aciduria\u2019 secondary to maternal atrophic gastritis"],"prefix":"10.1111","volume":"100","author":[{"given":"Wencke","family":"Weber\u2010Ferro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Hertzberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"R\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Timme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.1.7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197808172990701"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000325581.26991.f2"},{"key":"e_1_2_6_5_2","first-page":"19","article-title":"Cobalamine and folate deficiency: acquired and inheritary disorders in children","volume":"36","author":"Rosenblatt DS","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.1.131"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81897-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)90682-7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1402-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.061929"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981249"},{"key":"e_1_2_6_12_2","first-page":"72","article-title":"Aliment\u00e4rer Vitamin\u2010B12\u2010Mangel im S\u00e4uglins\u2010 und Kleinkindesalter \u2013 Entwicklung einer Epilepsie unter Substitutions\u2010therapie: Zwei Kasuistiken und Literatur\u00fcbersicht","volume":"9","author":"Fiedler BJ","year":"2010","journal-title":"Neuropaediatrie"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000316391.40236.c3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.02.012"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2011.02242.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2011.02242.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:56:03Z","timestamp":1697428563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2011.02242.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,24]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1651-2227.2011.02242.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2011.02242.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,24]]},"assertion":[{"value":"2011-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}