{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:43:27Z","timestamp":1792640607524,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T00:00:00Z","timestamp":1302048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Klinefelter syndrome (KS) (47,XXY) is the most common sex chromosome disorder in man and is a relatively common cause of male infertility and hypogonadism. The syndrome has been known since 1942, and many reports of different diseases associated with KS have been reported since that, but a more systematic knowledge about the long\u2010term outcome was not described until the last decade, where nation\u2010wide epidemiological studies were reported from Britain and Denmark. We here review the epidemiological data from two cohorts of patients with KS in Denmark and Britain, showing a significant increase in both mortality and morbidity from a variety of different causes. Mortality was increased by 50% (SMR 1.5 or HR 1.4) corresponding to a median loss of approximately 2\u2003years. The risk of being admitted to hospital with any diagnosis was increased by 70%. The underlying reason for the poorer health in KS may be caused by interaction of genetic, hormonal and socio\u2010economic factors.<\/jats:p><jats:p><jats:bold>Conclusion:\u00a0<\/jats:bold> Both morbidity and mortality are significantly increased in Klinefelter syndrome with a 50% increase in mortality risk and a 70% increase in risk of being admitted to hospital.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02274.x","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T14:52:36Z","timestamp":1300373556000},"page":"807-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Morbidity and mortality in Klinefelter syndrome (47,XXY)"],"prefix":"10.1111","volume":"100","author":[{"given":"Anders","family":"Bojesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus H","family":"Gravholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,6]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021491"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/183302a0"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0775"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.12.1309"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16678-6"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.2001.6520177.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1077"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji240"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0777"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0697"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-2-11-615"},{"key":"e_1_2_8_13_2","first-page":"115","article-title":"Chromosomal abnormalities in the New Haven newborn study: a prospective study of development of children with sex chromosome anomalies","volume":"15","author":"Leonard MF","year":"1979","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291918"},{"key":"e_1_2_8_15_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00278453","article-title":"Population cytogenetic investigation of newborns in Moscow","volume":"22","author":"Bochkov NP","year":"1974","journal-title":"Humangenetik"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.4.4.258"},{"key":"e_1_2_8_17_2","first-page":"209","article-title":"Sex chromosome abnormalities found among 34,910 newborn children: results from a 13\u2010year incidence study in Arhus, Denmark","volume":"26","author":"Nielsen J","year":"1990","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb01498.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)92405-5"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/003591577606900308"},{"key":"e_1_2_8_21_2","first-page":"261","article-title":"Summary of clinical findings: profiles of children with 47,XXY, 47,XXX and 47,XYY karyotypes","volume":"15","author":"Robinson A","year":"1979","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.2.192"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.39.4.330"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.85"},{"key":"e_1_2_8_25_2","first-page":"352","article-title":"Male breast cancer. 3. 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