{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:05:08Z","timestamp":1790643908197,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,5,5]],"date-time":"2011-05-05T00:00:00Z","timestamp":1304553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims:\u2002<\/jats:bold> (i) To compare the ratio of right ventricular systolic to diastolic duration (SD\/DD) in infants with congenital diaphragmatic hernia (CDH) and normal controls and (ii) to examine its association, if any, with outcomes in CDH.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Retrospective chart and echocardiographic review of consecutive neonates (&lt;1\u2003month old) with CDH and term controls without structural heart defects. Right ventricular SD\/DD was calculated by a single reader.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Infants with CDH (n\u2003=\u200329) were comparable to controls (n\u2003=\u200327) in their mean (SD) age [2.2 (3.3) vs. 2 (4.0) days], birthweight [3 (0.67) vs. 3 (0.69) kg] and proportion of males (48.2% vs. 72.4%). The DD and SD\/DD were significantly abnormal in the CDH group, compared to controls. Among infants with CDH, those who died (n\u2003=\u200315) and those who died or required ECMO (n\u2003=\u200317) had significantly shorter DD and higher SD\/DD ratio. At a cut\u2010off of 1.3, SD\/DD ratio had a sensitivity of 92.8 (95% CI 64\u201399%) and specificity of 61.5 (32\u201385%) for prediction of mortality. Significant independent associations with mortality were observed with antenatal diagnosis (p\u2003=\u20030.003) and higher SD\/DD ratio (p\u2003=\u20030.04).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The right ventricular SD\/DD ratio is a sensitive objective prognostic marker in infants with CDH. Further studies incorporating SD\/DD ratio as a guide to intervention are warranted.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02302.x","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T10:42:25Z","timestamp":1301654545000},"page":"1315-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The right ventricular systolic to diastolic duration ratio: a simple prognostic marker in congenital diaphragmatic hernia?"],"prefix":"10.1111","volume":"100","author":[{"given":"Sanjeev","family":"Aggarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T","family":"Stockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girija","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2010.03.001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.010"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951105001022"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.74.1.F26"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.127"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.11.014"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.03.048"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.05.034"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.05.024"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2011.02302.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2011.02302.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T20:59:02Z","timestamp":1697403542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2011.02302.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,5]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1651-2227.2011.02302.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2011.02302.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,5]]},"assertion":[{"value":"2011-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}