{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:59:20Z","timestamp":1761101960349},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,5,5]],"date-time":"2011-05-05T00:00:00Z","timestamp":1304553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To determine whether N\u2010terminal\u2010pro\u2010brain natriuretic peptide (NT\u2010proBNP) level could be an effective guide for early targeted indomethacin therapy for patent ductus arteriosus (PDA) in preterm infants.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> An interventional study involved preterm infants, born at &lt;33\u2003weeks of gestation, who had plasma NT\u2010proBNP levels obtained at day 2 of life. Indomethacin therapy was given if plasma NT\u2010proBNP level was \u226510\u2003180\u2003pg\/mL, the cut\u2010off for predicting hemodynamic significant PDA (hsPDA). Echocardiograms were performed within 6\u2003h at the time of plasma NT\u2010proBNP collection and again at day 7, or whenever clinical hsPDA was suspected. Primary outcomes were the incidence of later hsPDA and unnecessary exposure rate to indomethacin.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Fifty infants were enrolled. On day 2, 19 (38%) infants had plasma NT\u2010proBNP above the cut\u2010off and received indomethacin therapy; none of them developed later hsPDA, while 1 of 31 infants with NT\u2010proBNP below the cut\u2010off level developed clinical hsPDA. Unnecessary exposure to indomethacin occurred in two infants (11%). Overall, no enrolled infants had either reopening of ductus or PDA ligation.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Using NT\u2010proBNP level on day 2 as a guide for early targeted indomethacin therapy reduced later onset of hsPDA and the number of unnecessary exposures to indomethacin.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02304.x","type":"journal-article","created":{"date-parts":[[2011,4,4]],"date-time":"2011-04-04T05:39:25Z","timestamp":1301895565000},"page":"1217-1221","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["N\u2010terminal\u2010pro\u2010brain natriuretic peptide: a guide for early targeted indomethacin therapy for patent ductus arteriosus in preterm 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