{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:37:25Z","timestamp":1791275845256,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,7,27]],"date-time":"2011-07-27T00:00:00Z","timestamp":1311724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To analyse the association between prenatal paracetamol exposure and preschool wheeze.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Data were obtained from a prospective, longitudinal study of a cohort of children born in the region of western Sweden in 2003; 8176 families were randomly selected. The parents answered questionnaires at 6 and 12\u2003months and at 4.5\u2003years of age. The response rate was 55%, i.e. 4496 of the 5398 questionnaires distributed at 4.5\u2003years (83%). Inhaled corticosteroid (ICS) treated wheeze during the last year was regarded as a proxy for doctor\u2010diagnosed asthma. Episodic viral wheeze was defined as wheezing only with viral infections and multiple\u2010trigger wheeze as wheezing also in between infections.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In the multivariate analysis, the risk of ICS\u2010treated wheeze was increased by paracetamol (OR 1.6; 95% CI 1.01\u20132.6). Within the ICS\u2010treated group, the effect was significant for multiple\u2010trigger wheeze (OR 2.4; 1.2\u20134.8) but not for episodic viral wheeze (OR 1.1; 0.5\u20132.3).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Prenatal paracetamol exposure was an independent risk factor for ICS\u2010treated wheeze at preschool age, especially among children with ICS\u2010treated multiple\u2010trigger wheeze. Although the analysis adjusted for e.g. maternal asthma and antibiotic use, the possibility of residual confounding by maternal indication (respiratory illness) should be acknowledged.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02403.x","type":"journal-article","created":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T13:17:42Z","timestamp":1310995062000},"page":"1567-1571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Prenatal paracetamol exposure and risk of wheeze at preschool age*"],"prefix":"10.1111","volume":"100","author":[{"given":"Emma","family":"Goks\u00f6r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrefna","family":"Thengilsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernt","family":"Alm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Norvenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Wennergren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,27]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01984.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03378.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02151.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61445-2"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn070"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.121459"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4616"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.11.039"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.6.9612066"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.02.032"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1232"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002108"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.140418"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02411.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00209530"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.036"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036144"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00484.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60492-9"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000176304"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01942.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0865"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03691.x"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201005-0757OC"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181c225c0"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198207020-00001"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2003.00492.x"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02275.x"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63127-4"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61208-3"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.08.047"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2010.09.005"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2011.02403.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2011.02403.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:29:19Z","timestamp":1697416159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2011.02403.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,27]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1651-2227.2011.02403.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2011.02403.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,27]]},"assertion":[{"value":"2011-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}