{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:23:12Z","timestamp":1790652192870,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T00:00:00Z","timestamp":1315353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Aim:\u2002<\/jats:bold>\n                    To investigate the prevalence, co\u2010morbidities and aetiologies of severe mental retardation (SMR) in a cohort of Swedish children and to further penetrate aetiologies in the group with undetermined causes by application of updated clinical\u2010genetic methods.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    The study was population\u2010based and included children living in the County of Halland in western Sweden in 2004 (born 1987\u20131998; 46\u2003000 children). Patients were identified through habilitation centres, paediatric clinics and school health services. Patients with unclear prenatal aetiology were investigated with single nucleotide polymorphism (SNP)\u2010array.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Severe mental retardation was identified in 133 children from 132 families, corresponding to a prevalence of 2.9 per 1000 children. There were more males than females (90:43).The aetiology was prenatal in 82 (62%), perinatal in 14 (10%) and postnatal in 8 (6%). In 29 (22 %) children, mainly males with autism, the cause could not be related to the time of birth. In the prenatal group, genetic causes dominated, but still 23 children remained undiagnosed; in 5\/19 of these patients, a diagnosis could be made after SNP\u2010array analysis. One or more associated neurological handicaps were found in more than half of the children.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    Prevalence and co\u2010morbidity were similar to previous Scandinavian studies. High\u2010resolution chromosomal micro\u2010array techniques are valuable diagnostic tools, reducing the number of patients with unexplained SMR.\n                  <\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02417.x","type":"journal-article","created":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T09:23:34Z","timestamp":1310981014000},"page":"85-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Aetiology of severe mental retardation and further genetic analysis by high\u2010resolution microarray in a population\u2010based series of 6\u2010 to 17\u2010year\u2010old 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