{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:32:10Z","timestamp":1790260330818,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,8,19]],"date-time":"2011-08-19T00:00:00Z","timestamp":1313712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> Myocardial dysfunction is a frequent sequel of perinatal asphyxia. Cardiac troponin I (cTnI) is a marker of myocardial injury and a surrogate marker of myocardial dysfunction in adults, but there are few data in neonates. Our aim was to compare serum cTnI concentrations with clinical severity of encephalopathy and with duration of inotropic support in asphyxiated neonates.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Retrospective study of 60 neonates admitted with hypoxic\u2010ischaemic encephalopathy (HIE). cTnI concentrations measured within 36\u2003h of birth were compared with clinical grade of HIE (Sarnat\u2010Sarnat classification) and with duration of inotropic support.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Serum cTnI concentrations and duration of inotropic support were significantly greater with increasing severity of HIE. Median (95% CI) cTnI concentrations were 0.04\u2003\u03bcg\/L (0.02\u20130.07\u2003\u03bcg\/L) in grade 1 HIE, 0.12\u2003\u03bcg\/L (0.08\u20130.20\u2003\u03bcg\/L) in grade 2 HIE and 0.67\u2003\u03bcg\/L (0.41\u20131.35\u2003\u03bcg\/L) in grade 3 HIE. Median (95% CI) duration of inotropic support required was 0\u2003h (0\u201324\u2003h) in grade 1 HIE, 28\u2003h (0\u2013118\u2003h) in grade 2 HIE and 48\u2003h (0\u2013140\u2003h) in grade 3 HIE.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In asphyxiated neonates, cTnI concentrations within 36\u2003h of birth correlate strongly with clinical grade of HIE and with duration of inotropic support. Early cTnI concentrations may provide a useful proxy marker for the anticipated severity of myocardial dysfunction.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02432.x","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T20:50:27Z","timestamp":1311972627000},"page":"26-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Cardiac troponin I concentrations in neonates with hypoxic\u2010ischaemic encephalopathy"],"prefix":"10.1111","volume":"101","author":[{"given":"Aravind T","family":"Shastri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujeevan","family":"Samarasekara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemananda","family":"Muniraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,19]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"938","volume-title":"Fanaroff and Martin\u2019s Neonatal\u2010Perinatal medicine, disease of the fetus and infant","author":"Levene MI","year":"2006"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01780"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00804-4"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000112540"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/clinchem\/39.6.972","article-title":"Cardiac\u2010specific immunoenzymometric assay of troponin I in the early phase of acute myocardial infarction","volume":"39","author":"Larue C","year":"1993","journal-title":"Clin Chem"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000079068"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000089795"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/08035250510041222"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(96)00971-9"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2010.12.027"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802430834"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2011.02432.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2011.02432.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T01:06:19Z","timestamp":1697418379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2011.02432.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,19]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1651-2227.2011.02432.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2011.02432.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,19]]},"assertion":[{"value":"2011-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}