{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:59:33Z","timestamp":1761101973280},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T00:00:00Z","timestamp":1317686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> Patent ductus arteriosus (DA) occurs frequently in premature neonates with respiratory distress syndrome. We assessed a combination of clinical, biological and echocardiographic parameters to derive a decision rule for selecting candidates for treatment based on the criteria in use in our unit.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Hundred and forty neonates with a mean (SD) gestational age of 28 (2.3) weeks and a mean birth weight of 1159 (386)\u2003g, all requiring invasive ventilation with FiO<jats:sub>2<\/jats:sub>\u2003&gt;\u20030.3 or catecholamines for severe hypotension, were assessed prospectively using echocardiography in conjunction with N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NTpBNP) levels within 24\u201372\u2003h of birth. Independent predictors of DA treatment were identified with univariate analysis and combined in a clinical decision rule.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Early treatment of significant DA was adopted for 26 (18.6%) neonates. A clinical decision rule suggesting treatment in patients with NTpBNP\u2003&gt;\u20038500\u2003pg\/mL, ductal diameter &gt;1.5\u2003mm and, for infants with a birth weight &gt;830\u2003g, left pulmonary artery end\u2010diastolic velocity &gt;0.20\u2003m\/sec showed 88% sensitivity and 94% specificity.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> A decision rule using realistic and\/or commonly used parameters for significant patent ductus arteriosus assessment could be derived. External validation of this rule is needed before any application.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02469.x","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T03:39:33Z","timestamp":1316144373000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Can a clinical decision rule help ductus arteriosus management in preterm 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