{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:47:44Z","timestamp":1791496064825,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T00:00:00Z","timestamp":1320192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> Serum S100B and neuron\u2010specific enolase (NSE) levels are elevated after perinatal asphyxia, but the influence of hypothermia on these proteins has not been previously reported. The aim of this study was to evaluate the effect of systemic hypothermia on these protein levels after perinatal asphyxia, time course, and association with perinatal factors and neurodevelopmental outcome at 2\u2003years of age.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Serum S100B and NSE levels were measured at fixed time points in asphyxiated infants treated with standard intensive care on hypothermia (HT: n\u2003=\u200313) or normothermia (NT: n\u2003=\u200311).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Serum S100B and NSE levels were grossly elevated in both HT and NT groups. Compared with the values at 6\u2003h of age, S100B values decreased over time in both groups (NT: p\u2003=\u20030.002, HT: p\u2003=\u20030.04). Serum S100B values were lower in HT infants compared with those in NT infants (p\u2003=\u20030.047 at 48\u2003h). Serum S100B and NSE values were significantly higher in infants who died or developed severe neurological impairment (S100B, p\u2003&lt;\u20030.05 at all time points; NSE, p\u2003=\u20030.036 at 24\u2003h of age).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Both NSE and S100B levels are highly elevated following asphyxia. Serum S100B levels were lower in the HT group and strongly correlated with the neurodevelopmental outcome.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02480.x","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T21:13:57Z","timestamp":1318022037000},"page":"319-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Serum S100B and neuron\u2010specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia"],"prefix":"10.1111","volume":"101","author":[{"given":"Aniko","family":"Roka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya","family":"Kelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozsef","family":"Halasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Beko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Azzopardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miklos","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(88)90218-6"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(95)00040-2"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012691"},{"key":"e_1_2_7_5_2","first-page":"489","article-title":"Differential distribution of immunoreaqctive S100\u03b1 and S100\u03b2 proteins in normal non\u2010nervous human tissues","volume":"57","author":"Haimoto H","year":"1987","journal-title":"Lab Invest"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.7.998"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200104000-00011"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200206000-00037"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0711-4"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2007.02506.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720209788185614"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004298"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00442-1"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.10.1956"},{"key":"e_1_2_7_15_2","first-page":"61","article-title":"Serum neuron\u2010specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children","volume":"103","author":"Berger RP","year":"2005","journal-title":"J Neurosurg"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2009.10.012"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000052114"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1996.129282.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199707000-00012"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2003.12.007"},{"key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1542\/peds.93.2.234","article-title":"Neuron\u2010specific enolase and myelin basic protein: relationship of cerebrospinal fluid concentrations to the neurologic condition of asphyxiated full\u2010term infants","volume":"93","author":"Garcia\u2010Alix A","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c363"},{"key":"e_1_2_7_24_2","unstructured":"The TOBY study.Whole body hypothermia for the treatment of perinatal asphyxia encephalopathy. 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