{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:48:29Z","timestamp":1760122109307},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T00:00:00Z","timestamp":1321920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To quantify manual fraction of inspired oxygen (FiO<jats:sub>2<\/jats:sub>) adjustments performed by caregivers in extremely low birth weight (ELBW; \u22641000\u2003g) infants, in relation to oxygen saturation (SpO<jats:sub>2<\/jats:sub>) and bedside care.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In a single\u2010centre study, FiO<jats:sub>2<\/jats:sub>, SpO<jats:sub>2<\/jats:sub> and alarm limits of ELBW infants were collected for 3\u2003days continuously, while caregivers were filmed. A descriptive analysis, focused on manual FiO<jats:sub>2<\/jats:sub> adjustments, was performed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Twelve ELWB infants were included. Total recording time was 726\u2003h. FiO<jats:sub>2<\/jats:sub> was increased 851 times and decreased 1309 times; median (range) step size was 5% (1% to 65%) and \u22123% (\u22121% to \u221265%), respectively. Wide variation of FiO<jats:sub>2<\/jats:sub> adjustments for equal levels of SpO<jats:sub>2<\/jats:sub> was observed in all included infants. One hundred and twenty\u2010six of 136 FiO<jats:sub>2<\/jats:sub> adjustments with a step size \u226515% and 111 of 171 desaturations &lt;70% were associated with medical or nursing procedures. When FiO<jats:sub>2<\/jats:sub> was &gt;21%, alarm limits for SpO<jats:sub>2<\/jats:sub> were set according to protocol (88\u201394%) in 64% of the time. Within these periods, SpO<jats:sub>2<\/jats:sub> was &gt;94% for 30% and &lt;88% for 16% of the time.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Manual FiO<jats:sub>2<\/jats:sub> adjustments varied widely in frequency and step size. Deep desaturations and large FiO<jats:sub>2<\/jats:sub> adjustments were associated with medical or nursing procedures. When large adjustments are really necessary, it will be challenging to implement them in an automatic adjustment device.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02506.x","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T17:10:44Z","timestamp":1320081044000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["An observational study to quantify manual adjustments of the inspired oxygen fraction in extremely low birth weight infants"],"prefix":"10.1111","volume":"101","author":[{"given":"Anne Catherine","family":"van der 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