{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:10:05Z","timestamp":1783725005944,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,19]],"date-time":"2011-11-19T00:00:00Z","timestamp":1321660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To compare the incidence of hyponatremia in full\u2010term neonates with severe hyperbilirubinemia, receiving intravenous fluid supplementation with 0.2% saline in 5% dextrose versus 0.9% saline in 5% dextrose, to prevent blood exchange transfusion (BET).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In this double\u2010blind, randomized, controlled trial, full<jats:bold>\u2010<\/jats:bold>term newborns (\u226537\u2003weeks), appropriate for gestational age, with severe non\u2010haemolytic hyperbilirubinemia (serum bilirubin\u2003\u2265\u200320\u2003mg\/dL) were enrolled. Eligible neonates were randomized to receive either 0.2% saline in 5% dextrose (<jats:italic>hypotonic fluid group<\/jats:italic>) or 0.9% saline in 5% dextrose (<jats:italic>isotonic fluid group<\/jats:italic>) over 8 hrs, in addition to phototherapy. The primary outcome was proportion of neonates developing hyponatremia (serum Na\u2003&lt;\u2003135\u2003mmol\/L) after 8\u2003h.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Forty\u2010two neonates were analysed in each group. Proportion of neonates developing hyponatremia after 8\u2003h was higher in hypotonic fluid group as compared to isotonic fluid group (48.8% vs. 10.5%, p\u2003&lt;\u20030.001). However, a larger proportion in isotonic fluid group developed hypernatremia (39.5% vs. 12.2%, p\u2003&lt;\u20030.001). The rate of BET was similar in both groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In full\u2010term neonates with severe hyperbilirubinemia, administration of hypotonic fluid to prevent BET was associated with a higher incidence of hyponatremia while isotonic fluid was associated with an increased incidence of hypernatremia.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02508.x","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T17:11:22Z","timestamp":1320081082000},"page":"236-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Isotonic versus hypotonic fluid supplementation in term neonates with severe hyperbilirubinemia \u2013 a double\u2010blind, randomized, controlled 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