{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:01:50Z","timestamp":1782961310763,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T00:00:00Z","timestamp":1324598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> In preterm infants, inflammation and intra\u2010alveolar fibrin formation characterize respiratory distress syndrome (RDS). Tissue factor (TF) is a link between inflammation and coagulation pathways. We investigated the relationship between TF and cytokines in preterm infants to gain information of the role of TF in the inflammatory response.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We measured TF in plasma and in tracheal aspirates and analysed TF on monocytes by flow cytometry and 13 cytokines from plasma, in 56 preterm infants (birthweight 600\u20131500\u2003g) during their first week.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Plasma TF increased and peaked on day 3 and correlated with both RDS and inversely with paO2\/FIO2. On day 1, TF in tracheal aspirates was 10\u2010fold higher than in plasma and correlated with plasma TF (4888 vs. 506\u2003pg\/mL, R\u2003=\u20030.692, p\u2003=\u20030.013, n\u2003=\u200312). Of main pro\u2010inflammatory cytokines, plasma TF correlated post\u2010natally with IL\u20108 and IL\u20106 but not with IL\u20101 or TNF\u2010\u03b1.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Respiratory morbidity associates with high TF in lungs and plasma. In sick newborn infants, upregulation of TF may be mediated by IL\u20106 and IL\u20108. High TF and pro\u2010inflammatory cytokines may together participate in the pathogenesis of pulmonary and extrapulmonary injury in preterm infants through pro\u2010inflammatory mechanisms.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2011.02537.x","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T15:29:46Z","timestamp":1321975786000},"page":"403-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High tissue factor in lungs and plasma associates with respiratory morbidity in preterm 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