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This study aimed at investigating the possible effect of persistent patent ductus in VLBW infants.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The study included 177 VLBW infants born at 25\u201331\u2003weeks of gestation from January 2006 to May 2011. Mortality and major morbidities were compared between infants with a persistent patent ductus (n\u2003=\u200333) and those without it (n\u2003=\u2003104). Statistical associations between potential neonatal risk factors and significant morbidities were identified using multivariate regression analyses.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Rates of mortality and major morbidities, including the rate of bronchopulmonary dysplasia, necrotizing enterocolitis, intraventricular haemorrhage grades I\u2013II and III\u2013IV, periventricular leucomalacia, late\u2010onset infections and failure of hearing screening, were insignificantly higher in VLBW infants with a persistent patent ductus than in those without it.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This study adds further evidence that persistent patent ductus arteriosus has no significant effect on mortality and morbidity in VLBW infants born at \u226525\u2003weeks\u2019 gestational 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