{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:54:12Z","timestamp":1758473652408},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To evaluate the occurrence of autoimmune diseases in first\u2010degree relatives of children with juvenile idiopathic arthritis (JIA) and to compare the figures with published population data.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> Families of the 362 children with recently diagnosed JIA admitted to Rheumatism Foundation Hospital, Finland, from 1996 to 2001 were contacted by questionnaires regarding autoimmune diseases in family members. Data were collected on type 1 diabetes, coeliac disease, multiple sclerosis and chronic arthritis, consisting mainly of JIA, rheumatoid arthritis, spondyloarthropathy or psoriatic arthritis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In all, 21.4% of the 355 families with a patient with JIA had members with type 1 diabetes, coeliac disease, multiple sclerosis or chronic arthritis. Thirty\u2010three mothers and 23 fathers had type 1 diabetes, coeliac disease, multiple sclerosis or chronic arthritis in 15.2% (95% CI 11.6\u201319.4) of the families, and 23 mothers and 15 fathers had chronic arthritis in 10.7% (95% CI 7.7\u201314.5) of the families. When compared with available research data, the prevalences of rheumatoid arthritis, spondyloarthropathy, psoriatic arthritis, paediatric type 1 diabetes and JIA (in siblings) were increased in JIA families. Coeliac disease was as prevalent as in the population.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Autoimmune diseases cluster in families with a child with JIA.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2012.02658.x","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T15:00:27Z","timestamp":1330959627000},"page":"767-771","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diabetes, coeliac disease, multiple sclerosis and chronic arthritis in first\u2010degree relatives of patients with juvenile idiopathic arthritis"],"prefix":"10.1111","volume":"101","author":[{"given":"Heini","family":"Pohjankoski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Kautiainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisu","family":"Kotaniemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneli","family":"Savolainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,27]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh531"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10370"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24187"},{"key":"e_1_2_8_5_2","article-title":"The Distribution of rheumatoid arthritis, spondylitis and multiple rheumatoid arthritis in a single large kindred","volume":"2","author":"Wittinghill M","year":"1958","journal-title":"Proc X Int Congr Genet, Montreal"},{"key":"e_1_2_8_6_2","first-page":"263","article-title":"Occurrence of chronic inflammatory rheumatic diseases among parents of multiple offspring affected by juvenile idiopathic arthritis","volume":"21","author":"S\u00e4il\u00e4 H","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20677"},{"key":"e_1_2_8_8_2","first-page":"2525","article-title":"Quantification of the familial contribution to juvenile idiopathic arthritis","volume":"62","author":"Prahalad S","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02231580"},{"key":"e_1_2_8_10_2","first-page":"88","article-title":"Different familial association patterns of autoimmune diseases between juvenile\u2010onset systemic lupus erythematosus and juvenile rheumatoid arthritis","volume":"37","author":"Huang CM","year":"2004","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4412"},{"key":"e_1_2_8_12_2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0778-8"},{"key":"e_1_2_8_14_2","first-page":"1674","article-title":"The ARA 1987 Revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered from drug reimbursement","volume":"20","author":"Hakala M","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_8_15_2","first-page":"496","article-title":"Incidence and prevalence of ankylosing spondylitis in Finland","volume":"24","author":"Kaipiainen\u2010Sepp\u00e4nen O","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009740802609558"},{"key":"e_1_2_8_17_2","author":"Lantto R","year":"1985","journal-title":"Juvenile rheumatoid arthritis in northern Finland"},{"key":"e_1_2_8_18_2","first-page":"367","article-title":"Juvenile arthritis \u2013 who gets it, where and when? 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