{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T02:56:43Z","timestamp":1772679403308,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T00:00:00Z","timestamp":1333929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The aim of the study was to evaluate the effects of hypothermia on neuron\u2010specific enolase (NSE) and S\u2010100 protein levels in cerebrospinal fluid (CSF) in neonates with hypoxic\/ischaemic encephalopathy (HIE).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Fifty\u2010one enrolled neonates with HIE were divided into two groups: hypothermia (n\u2003=\u200323) and control (n\u2003=\u200328). NSE and S\u2010100 protein were measured with immunoradiometric assays. Amino acid neurotransmitters were also measured by reversed\u2010phase high\u2010performance liquid chromatography. Neurodevelopmental assessments were performed at 3 and 12\u2003months of age.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Neuron\u2010specific enolase and S\u2010100 levels were lower, and neurodevelopment outcome was better in the hypothermia group compared with the control group. Among the infants who received hypothermia, CSF NSE and S\u2010100 were significantly higher in those who developed severe neurological impairment (mental development index or physical development index &lt;70). There were no significant differences between the two groups in amino acid neurotransmitters.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These results indicated that hypothermia was associated with decreased CSF NSE and S\u2010100 level and correlated with neurodevelopmental outcome in infants with HIE.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2012.02679.x","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T18:10:49Z","timestamp":1332871849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effects of hypothermia on NSE and S\u2010100 protein levels in CSF in neonates following hypoxic\/ischaemic brain damage"],"prefix":"10.1111","volume":"101","author":[{"given":"Jinqiao","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.43"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2441"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.03.030"},{"key":"e_1_2_7_8_2","first-page":"61","article-title":"Serum neuron\u2010specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children","volume":"103","author":"Berger RP","year":"2005","journal-title":"J Neurosurg"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(95)00040-2"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.10.1956"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.1.F39"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2010.03290.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200104000-00011"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2003.12.007"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2004.11.010"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(91)90191-5"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119153"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10402"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.2741\/2104"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.04.003"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01437-3"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02480.x"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2012.02679.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2012.02679.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:39:01Z","timestamp":1697431141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2012.02679.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,9]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1651-2227.2012.02679.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2012.02679.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,9]]},"assertion":[{"value":"2012-04-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}