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These hypoxia\u2010generated mediators include the Krebs cycle intermediate, succinate acting via GPR91, and the neuronal guidance molecule Semaphorin 3A.<jats:bold>Conclusion:<\/jats:bold>\u2002Neuron\u2010derived factors guide retinal vascularization and are major contributors to the pathogenesis of ROP.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2012.02692.x","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T18:13:36Z","timestamp":1334254416000},"page":"819-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 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