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Furosemide, because of its actions on the ubiquitous Na<jats:sup>+<\/jats:sup>\u2013K<jats:sup>+<\/jats:sup>\u20132Cl<jats:sup>\u2212<\/jats:sup>isoform cotransporter and its promotion of prostanoid production and release, also has non\u2010diuretic effects on vascular smooth muscle, airways, the ductus arteriosus and theoretically the gastrointestinal tract. Loop diuretics also affect the central nervous system through modulation of the GABA\u2010A chloride channel.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>The loop diuretics have a variety of biological effects that are potentially harmful as well as beneficial. Care should be taken with the use of these agents because the range of their effects may be broader than the single action sought by the prescribing physician.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2012.02699.x","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T15:19:28Z","timestamp":1335453568000},"page":"835-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Unexpected extra\u2010renal effects of loop diuretics in the preterm neonate"],"prefix":"10.1111","volume":"101","author":[{"given":"Robert","family":"Cotton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Reese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,28]]},"reference":[{"key":"e_1_2_16_2_2","volume-title":"Goodman & Gilman\u2019s the pharmacological basis of therapeutics","author":"Reilly RF","year":"2011"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020521308985"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809333526"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(76)80478-7"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1707"},{"key":"e_1_2_16_7_2","first-page":"583","article-title":"[Diuretics in the neonatal period]","volume":"115","author":"Guignard JP","year":"1995","journal-title":"Rev Med Suisse Romande"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80708-5"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80451-X"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050560"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80146-5"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0700922"},{"key":"e_1_2_16_13_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0026-895X(25)08539-6","article-title":"Selective antagonist for the cerebellar granule cell\u2010specific gamma\u2010aminobutyric acid type A receptor","volume":"47","author":"Korpi ER","year":"1995","journal-title":"Mol Pharmacol"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(99)00040-3"},{"key":"e_1_2_16_15_2","volume-title":"Goodman & Gilman\u2019s the pharmacological basis of therapeutics","author":"Molinoff PB","year":"2011"},{"key":"e_1_2_16_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.01.004"},{"key":"e_1_2_16_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91314.2008"},{"key":"e_1_2_16_18_2","first-page":"133","volume-title":"Hyaline membrane disease. 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