{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:10:26Z","timestamp":1790511026837,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims:\u2002<\/jats:bold> Loss of specific immunity follows allogeneic haematopoietic stem cell transplantation (HSCT) in the majority of cases. Responses to (re)vaccinations can be used as indicators of a functional immunological recovery.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty\u2010three paediatric recipients of HSCT were enrolled in a single centre setting and responses to scheduled immunizations analysed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Immunity to vaccine\u2010preventable diseases was impaired post HSCT, but (re)vaccinations induced protective responses in 59\u2013100%, depending on the vaccine, regardless of prior graft\u2010versus\u2010host disease (GVHD) history.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Despite the marked impact of moderate to severe chronic prior GVHD on both the qualitative and quantitative T\u2010cell recovery post allogenic HSCT, most paediatric recipients of allogeneic stem cell grafts appear to attain protective antibody levels after immunization.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2012.02710.x","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T15:22:24Z","timestamp":1335453744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Immunity after (re)vaccination of paediatric patients following haematopoietic stem cell 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