{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:34:17Z","timestamp":1790048057354,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The aim of this study was to investigate the role of congenital cytomegalovirus (CMV) infection as a cause of various types of sensorineural hearing loss (SNHL) in a group of nonsyndromic children with otherwise unknown aetiology of hearing loss. Furthermore, the occurrence of combined congenital CMV infection and connexin 26 (Cx26) mutations was investigated.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The dried blood spot (DBS) cards of 45 children with various degrees of hearing deficits and 46 children with severe\/profound hearing loss were tested for CMV DNA with polymerase chain reaction (PCR) technique. The DBS cards of the 46 children with severe\/profound hearing loss were also analysed for Cx26 mutations.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the 45 children with various degrees of hearing loss, nine were positive for CMV DNA (20%). The nine children represented severe\/profound, mild and unilateral hearing loss. From the 46 children with severe\/profound hearing loss, nine of 46 (20%) were positive for CMV DNA. In addition, three of the CMV DNA\u2010positive children were carriers of mutations of Cx26.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Congenital CMV infection is a high risk factor in hearing impairment among children.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2012.02711.x","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T17:46:35Z","timestamp":1334943995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Congenital cytomegalovirus infection \u2013 a common cause of hearing loss of unknown 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