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The unique combination of tissue protective, smooth muscle relaxing and angiogenesis regulatory properties makes HO\u20101 a key player in the maintenance of a healthy pregnancy through a direct effect on placental structural and vascular development, thus affecting foetal development.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Therefore, we conclude that HO\u20101 plays an important role in placental vasculature development and a deficiency in HO\u20101 may contribute to pregnancy complications, such as pre\u2010eclampsia, spontaneous abortions and premature births.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2012.02729.x","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T19:46:22Z","timestamp":1337283982000},"page":"827-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A deficiency in haem oxygenase\u20101 induces foetal growth restriction by placental 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