{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:09:21Z","timestamp":1790809761902,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims:\u2002<\/jats:bold> We investigated whether plasma lactate dehydrogenase (LDH) predicts outcome in hypothermia (HT)\u2010treated term infants with moderate\/severe hypoxic\u2010ischaemic encephalopathy (HIE) and additionally whether LDH differs between infants with evidence for acute and nonacute perinatal insults and postnatal collapse (PNC).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Data from HT\u2010treated infants with HIE (n\u2003=\u200339) were analysed retrospectively. Adverse outcome was defined as a Mental and\/or Psychomotor Developmental Index (Bayley Scales of Infant Development II), at 18\u2003months &lt;70. The likely timing of insult onset was assessed in infants with an LDH sample obtained within 6\u2003h of birth or PNC (n\u2003=\u200320).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> LDH differed between the favourable\/adverse outcome groups at the end of HT treatment (median (IQR) 1540 (1400\u20131950)U\/L vs. 3555 (3003\u20138705)U\/L, (p\u2003&lt;\u20030.01)). All infants (n\u2003=\u200322) with LDH &lt;2085U\/L had a favourable outcome while 6 of 11 infants with LDH\u2003\u2265\u20032085U\/L had an adverse outcome. LDH in those who died (n\u2003=\u20034) was higher than the favourable outcome group (5090 (2915\u201312222)U\/L, (p\u2003&lt;\u20030.01)) but sampled earlier. Early LDH differed significantly (p\u2003&lt;\u20030.01) between infants with evidence for acute or nonacute insults or PNC.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These results offer a biomarker, with high negative predictive value in the assessment of outcome in HT\u2010treated term infants, needing prospective validation.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2012.02778.x","type":"journal-article","created":{"date-parts":[[2012,7,8]],"date-time":"2012-07-08T01:06:55Z","timestamp":1341709615000},"page":"1038-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Lactate dehydrogenase in hypothermia\u2010treated newborn infants with hypoxic\u2010ischaemic encephalopathy"],"prefix":"10.1111","volume":"101","author":[{"given":"Marianne","family":"Thoresen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Jary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemmen","family":"Sabir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12658-X"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440701"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.099846"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.1.F34"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2938"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02327.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.2.323"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70295-9"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2441"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971127"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.05.008"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.06.003"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01653.x"},{"key":"e_1_2_8_19_2","first-page":"601","volume-title":"Enzymes. 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