{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T12:42:38Z","timestamp":1748608958432},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:00:00Z","timestamp":1345680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> Growing numbers of newborns are saved from HIV infection through increased access to mother\u2010to\u2010child transmission prevention programmes. The maternally derived humoral immunity of these children might be impaired, both in terms of quantity and in terms of quality, with consequences for the timing of immunization against measles.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A cell\u2010ELISA technique compared the neutralizing activity on Edmonston strain measles virus of sera from 1\u2010 to 4\u2010month\u2010old infants. Ten serum specimens came from noninfected infants of HIV\u2010infected mothers and another 10 from infants of healthy mothers. The sera were matched for the level of conventional ELISA measles antibodies.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Reflecting infection of the Vero cells by non\u2010neutralized virus, optical density values were significantly higher for the sera from the children of the HIV\u2010infected mothers than for those of the noninfected mothers (p\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Maternally derived protection against measles may be impaired by the mother\u2019s HIV infection, relating to the quality rather than to the quantity of transplacental antibodies. Selective, early immunization with live attenuated measles vaccine should be evaluated in noninfected children of HIV\u20101\u2010infected mothers.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2012.02793.x","type":"journal-article","created":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T06:12:04Z","timestamp":1342851124000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impaired neutralizing activity by transplacental measles antibodies in infants born to HIV\u20101\u2010infected mothers"],"prefix":"10.1111","volume":"101","author":[{"given":"S","family":"Farouk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Nav\u00e9r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Smedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir111"},{"issue":"1","key":"e_1_2_9_3_2","first-page":"S4","article-title":"Proceedings of the global technical consultation to assess the feasibility of measles eradication, 28\u201330 July 2010","volume":"204","author":"WHO","year":"2011","journal-title":"J Infect Dis"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.79.3.F202"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000168179.68781.95"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/522989"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir071"},{"key":"e_1_2_9_8_2","first-page":"641","article-title":"Interventions for the control of diarrhoeal diseases among young children: measles immunization","volume":"61","author":"Feachem RG","year":"1983","journal-title":"Bull World Health Organ"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540801894787"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(98)00041-X"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/429963"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2375"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/605648"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2012.02793.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2012.02793.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T23:41:40Z","timestamp":1697413300000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2012.02793.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,23]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1651-2227.2012.02793.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2012.02793.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,23]]},"assertion":[{"value":"2012-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}