{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:35:04Z","timestamp":1785767704140,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T00:00:00Z","timestamp":1330473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Purpose:<\/jats:bold> Different biomaterials have been suggested for guided bone regeneration (GBR). These might show the ideal properties to let a new bone formation in the grafted area. Among these ideal features, it is essential their controlled resorption in order to be replaced for new vital bone. Bovine bone has been used widely as a good biomaterial for GBR, however there is still an interesting controversy about its resorbable capacity. In this sense, the objective of this study was to examine the behavior of anorganic bovine bone (ABB) in long\u2010term maxillary sinus graft healing and study its relationship with morphological and morphometrical variables.<\/jats:p><jats:p><jats:bold>Materials and Methods:<\/jats:bold> Seventeen maxillary sinus augmentation procedures were performed in patients. Bone cores were obtained from implant receptor sites at 6 months, 3 years, and 7 years of implant placement for histological, morphometric, and immunohistochemical (tartrate resistant acid phosphatase [TRAP]\/cathepsin K\/CD68) studies.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The percentages of bone, ABB particles, connective tissue, osteocytes, and osteoblasts in maxillary sinus grafts were similar at 6 months, 3 years, and 7 years. A progressive and significant decrease was detected in osteoclasts (<jats:italic>p<\/jats:italic>\u2003=\u2003.05, Kruskal\u2010Wallis test), TRAP and cathepsin K expression (<jats:italic>p<\/jats:italic>\u2003=\u2003.014 and <jats:italic>p<\/jats:italic>\u2003=\u2003.021, respectively), and osteoid lines (<jats:italic>p<\/jats:italic>\u2003=\u2003.038).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> According to these data, a decrease in osteoclasts over time may, partially, explain the ABB persistence observed in core biopsies. Further studies with more cases and different graft maturation times are required to elucidate the resorption rates and cell events underlying these phenomena.<\/jats:p>","DOI":"10.1111\/j.1708-8208.2012.00445.x","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T17:02:34Z","timestamp":1330534954000},"page":"858-866","source":"Crossref","is-referenced-by-count":61,"title":["Slow Resorption of Anorganic Bovine Bone by Osteoclasts in Maxillary Sinus 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